Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls

Inclusion criteria patients:

1. Adult patients with confirmed diagnosis of Arginine Vasopressin deficiency (centraldiabetes insipidus)2 or with only anterior pituitary deficiency

Inclusion criteria healthy controls:

1. Adult healthy controls

2. Matched for age, sex, Body mass index, and oestrogen replacement/menopause/hormonalcontraceptives to patients

3. No medication, except hormonal contraception

Exclusion Criteria:

1. Participation in a trial with investigational drugs within 30 days

2. Illicit substance use (except for cannabis) more than 10 times in lifetime or anytime within the previous two months

3. Consumption of alcoholic beverages >15 drinks/week

4. Tobacco smoking >10 cigarettes/day

5. Cardiovascular disease (coronary artery disease, heart failure Left ventricularejection fraction <40%, stroke in the last 3 months, atrial fibrillation/flatter,Wolff-Parkinson-White-Syndrome)

6. Uncontrolled arterial hypertension (>140/90 mmHg) or hypotension (<85mmHg)

7. Current or previous major psychiatric disorder (e.g., major depression,schizophrenia spectrum disorder)

8. Psychotic disorder in first-degree relatives

9. Regular intake of selective serotonin reuptake inhibitors or Monoamine oxidaseinhibitors

10. Pregnancy and breastfeeding

11. Diagnosed Chronic Kidney Disease > grade III (glomerular filtration rate < 30ml/min)

12. Diagnosed liver cirrhosis or alanine aminotransferase (ALAT) or aspartateaminotransferase (ASAT) levels 2.5 times above the normal range