Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial

Last updated: April 13, 2026
Sponsor: Xijing Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetic Kidney Disease

Diabetic Foot Ulcers

Diabetes Prevention

Treatment

VA（anesthesia with sevoflurane and remifentanil）

TIVA ( anesthesia with propofol and remifentanil)

Clinical Study ID

NCT06788743
NCT06788743
  • Ages > 60
  • All Genders

Study Summary

The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years. The participants will be randomly assigned in a 1:1 ratio and will receive either propofol or sevoflurane for intraoperative anesthesia maintenance to evaluate the impact of these two anesthetic drugs on postoperative delirium. The aim of our study is to explore whether the use of propofol for anesthesia maintenance in elderly diabetic patients undergoing elective non-cardiac major surgery can reduce the incidence of postoperative delirium. This study will provide new perspectives for improving perioperative management in elderly diabetic patients and optimizing anesthesia management strategies to reduce the risk of postoperative delirium.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥60 years

  • Elective surgery (with an expected duration of 2 hours or more)

  • ASA grade Ⅰ-Ⅲ

  • Voluntary participation and informed consent obtained

  • Diabetes mellitus

Exclusion

Exclusion Criteria:

  • Pre-operative BMI≥35 kg/m² (Class II obesity or above)

  • Severe hepatic dysfunction (Child-Pugh class C) or pre-operative dialysis-dependentrenal dysfunction

  • Known neurological or psychiatric diseases (Parkinson's disease, depression,schizophrenia), or cognitive impairment (dementia)

  • Severe visual or auditory impairments, language barriers, or patients who cannotcooperate

  • Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse

  • Neurosurgical patients

  • Patients with a known allergy to the drugs used in this study or those suspected ofhaving propofol infusion syndrome

Study Design

Total Participants: 450
Treatment Group(s): 2
Primary Treatment: VA（anesthesia with sevoflurane and remifentanil）
Phase:
Study Start date:
June 01, 2025
Estimated Completion Date:
May 31, 2026

Connect with a study center

  • The First Affiliated Hospital of Air Force Medical University

    Xi'an, Shanxi 710032
    China

    Site Not Available

  • The First Affiliated Hospital of Air Force Medical University

    Xi’an, Shanxi 710032
    China

    Active - Recruiting

  • The First Affiliated Hospital of Air Force Medical University

    Xi’an 11474004, Shanxi 1795912 710032
    China

    Site Not Available

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