Incorporating Healthy Living Strategies to Aid in Recovery After Acute Pulmonary Embolism

Last updated: March 4, 2025
Sponsor: University of Rochester
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cardiovascular Disease

Circulation Disorders

Chest Pain

Treatment

Healthy Living Intervention-2

Healthy Living Intervention-1

Clinical Study ID

NCT06784492
STUDY00009895
1K23HL171867
  • Ages > 18
  • All Genders

Study Summary

The purpose of the ERAsE-PE study is to determine whether two different healthy living strategies (along with anticoagulation) might aid in recovery after a patient is hospitalized for pulmonary embolism. Specifically, Investigators will compare changes in Cardiac Effort (#heart beats used during the 6-minute walk test/walk distance) measured after an 8-week program.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. English speaking (>18 years old). Daily messages will be sent in English.

  2. Acute PE with at least one of the following:

  3. any right ventricular enlargement or dysfunction on echocardiogram;

  4. CT Angiogram reporting any right ventricular enlargement; or

  5. elevated cardiac biomarker (NT-pro BNP or troponin above baseline). Criteriafor enrollment will be included on source document.

  6. Rate controlled atrial arrythmias (resting heart rate <110 beats/m) are eligible forenrollment. This includes atrial fibrillations. This is standard of care managementfor atrial fibrillation.

  7. Subjects do need to take prescribed anticoagulation.

Exclusion

Exclusion Criteria:

  1. Pregnancy.

  2. Cardiac Effort >3.5 beats/m during 6MWT.

  3. Resting tachycardia >110 beats/m at hospital discharge.

  4. Chronic Thromboembolic Pulmonary Hypertension

  5. Systolic blood pressure >180 mmHg at hospital discharge.

  6. Inability to walk.

  7. Estimated prognosis <12 months at the time of discharge due to underlyingco-morbidities (e.g., cancer).

  8. Advanced neurologic disease and would not be able to comply with the messages.

  9. Lack of access to email or text messaging 10. Inability or unwillingness to followdaily instructions.

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Healthy Living Intervention-2
Phase:
Study Start date:
February 27, 2025
Estimated Completion Date:
December 01, 2027

Connect with a study center

  • University of Rochester Medical Center

    Rochester, New York 14620
    United States

    Active - Recruiting

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