Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure

Inclusion Criteria for Cordella PA Sensor System Cohort:

• Received Cordella PA Sensor System implant between 10/1/2024-12/31/2029

• Documented chronic heart failure with NYHA Class III symptoms

• On guideline-directed medical therapy based on ejection fraction status:

• For reduced EF (≤40%): At least one fill of ACE/ARB/ARNI, MRA, BB, or SGLT2i,and one fill of a loop diuretic

• For preserved EF (>40%): At least one fill of a loop diuretic

• Has continuous health insurance enrollment for 12 months prior to implant

Inclusion Criteria for Standard of Care Control Cohort:

• Two or more encounters with diagnosis codes for chronic systolic and/or diastolicheart failure

• Documented ejection fraction reading within 6 months (+ or -) of second heartfailure encounter

• On guideline-directed medical therapy based on ejection fraction status:

• For reduced EF (≤40%): At least one fill of ACE/ARB/ARNI, MRA, BB, or SGLT2i,and one fill of a loop diuretic

• For preserved EF (>40%): At least one fill of a loop diuretic

• Has continuous health insurance enrollment for 12 months prior to study entry

Exclusion Criteria:

• No implanted pulmonary artery sensor or monitoring at any time (Standard of CareControl Cohort only)

• Record of temporary mechanical circulatory support during baseline period

• Diagnosis of cardiogenic shock during baseline period

• Receiving palliative care/hospice during baseline period

• Record of end-stage renal disease during baseline period

• Unable to take dual antiplatelet therapy or anticoagulants for one month postimplant (Cordella Cohort only)