Ibuprofen Arginine and Neural Mobilization Versus Ibuprofen Arginine in the Treatment of Carpal Tunnel Syndrome

Last updated: September 19, 2025
Sponsor: Universidad Europea de Madrid
Overall Status: Completed

Phase

4

Condition

Carpal Tunnel Syndrome

Pain

Treatment

Ibuprofen Arginine

median nerve neural mobilization combined with oral ibuprofen arginine

Clinical Study ID

NCT06778759
CE0072015-02-07
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

In the present investigation the pain reduction effects of a physiotherapy technique combined with pharmaceutical ibuprofen arginine treatment will be compared to those produced by ibuprofen (only) treatment, in subjects who suffer the signs and symptoms of carpal tunnel syndrome.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants must be medically diagnosed with unilateral carpal tunnel syndrome (with confirmative electrodiagnostic findings).

  • Full understanding of written and spoken Spanish (language).

  • Participants must freely consent to participate.

  • The presence of positive Phalen an Tinel sings.

  • The presence of carpal tunnel syndrome signs and symptoms

Exclusion

Exclusion Criteria:

  • The lack to meet inclusion criterions, the presence of cognitive impairment, tumors,cancer, recent (affected) upper limb surgery or trauma, pregnancy, kinesiophobia,deformities of the (affected) upper limb, recent skin injuries or infections (in theaffected upper limb), autoimmune inflammatory conditions or flu type symptoms,allergy to gabapentin, allergy to ibuprofen arginine, and also: participants mustnot be (during the present investigation) under any type of pain reducing treatment (conservative, homeopathic, invasive or not invasive)

Study Design

Total Participants: 27
Treatment Group(s): 2
Primary Treatment: Ibuprofen Arginine
Phase: 4
Study Start date:
February 19, 2025
Estimated Completion Date:
March 19, 2025

Study Description

The present randomized clinical trial will perform a comparison of the pain reduction effects produced by the application of a non invasive and non pharmacological median nerve neural mobilization (physiotherapy treatment) combined with a pharmaceutical oral ibuprofen arginine treatment, to those effects produced by a ibuprofen arginine (only) treatment. Additionally, effects over the functionality of the affected upper limb will be evaluated and compared. Subjects will be invited to participate and randomly allocated to 2 different groups.

Connect with a study center

  • Ciudad Hospitalaria Enrique Tejera

    Valencia, Carabobo 02001
    Venezuela

    Site Not Available

  • Ciudad Hospitalaria Enrique Tejera

    Valencia 3625549, Carabobo 3646751 02001
    Venezuela

    Site Not Available

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