STI Prophylaxis and Emergence of Antimicrobial Resistance

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06778083

174194

REC Ref: 24/EM/0282

Ages > 18
Male
Accepts Healthy Volunteers

Study Summary

The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted infections (STI prophylaxis, doxycycline post-exposure prophylaxis, or 'doxyPEP'). The study will assess how easy and acceptable it is to find antibiotic resistance and microbiome changes in the throats and guts of men-who-have-sex-with-men (MSM) who use STI prophylaxis.

The study will recruit 108 MSM who are using and not using STI prophylaxis. Participants will visit the clinic every 6 months. At each visit, they will provide a throat swab and stool sample, and complete a questionnaire. DNA of the bacteria from the samples will be analysed to identify the bacteria and look for antibiotic resistance.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Aged ≥ 18 years.
Identifies as a man (cis or trans).
Has sex with men.
Able to provide informed consent.

Exclusion

Exclusion Criteria:

Use of an antibiotic other than doxycycline in the 3 months prior to enrolment
Currently being treated for an STI with doxycycline
Use of doxycycline within the prior 3 months for an indication other than STItreatment or STI prevention.

Study Design

February 10, 2025

April 30, 2027

Connect with a study center

Central and North West London NHS Foundation Trust
London,
United Kingdom
Active - Recruiting

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