Asthma is the most common chronic respiratory disease worldwide, characterized by
inflammation in the respiratory tract accompanied by bronchoconstriction, edema, and
increased mucosa. Oxidative stress causes smooth muscle contraction, proliferation, and
hypersensitivity of the airways, while hypoxia and systemic inflammation weaken the
respiratory muscles. Lung hyperinflation in asthmatic patients causes an increase in the
work of breathing. The increased workload on the respiratory muscles increases the
respiratory frequency and causes dyspnea.
Pharmacological agents, allergen avoidance, lifestyle modification, anti-IgE antibodies
and selectively alternative/complementary drugs or non-pharmacological methods (including
breathing exercises, pulmonary rehabilitation, yoga and inspiratory muscle training) are
applied in the treatment of asthma. Exercise training; it has been reported to improve
asthma symptoms, quality of life, exercise capacity, bronchial hyperresponsiveness,
exercise-induced bronchoconstriction and cardiopulmonary fitness and reduce airway
inflammation and nighttime symptoms in asthmatic patients. In addition, asthma control
can be increased with appropriate timing and intensity of exercise-based PR. The
physiological effect of inspiratory muscle training is to weaken the metaboreflex
mechanism, possibly reducing the activity of chemosensitive afferents and sympathetic
nerve stimulation. Inspiratory muscle training stimulates structural and biochemical
adaptations within the inspiratory muscles. It is stated in the literature that
physiotherapy approaches such as breathing exercises and respiratory muscle training
provide clinical benefits by increasing inspiratory muscle strength and reducing symptoms
and the need for bronchodilators.
In recent years, the role of lncRNAs has also been emphasized in studies conducted on
asthma patients. LncRNAs are long non-coding RNAs and there are studies indicating that
they play an important role in the regulation of asthma. However, there is no study in
the literature examining the effect of exercise training on lncRNA MALAT1 in asthmatic
patients. Asthma is the most common chronic respiratory disease worldwide, characterized
by inflammation in the respiratory tract accompanied by bronchoconstriction, edema, and
increased mucosa. Oxidative stress causes smooth muscle contraction, proliferation, and
hypersensitivity of the airways, while hypoxia and systemic inflammation weaken the
respiratory muscles. Lung hyperinflation in asthmatic patients causes an increase in the
work of breathing. The increased workload on the respiratory muscles increases the
respiratory frequency and causes dyspnea.
Pharmacological agents, allergen avoidance, lifestyle modification, anti-IgE antibodies
and selectively alternative/complementary drugs or non-pharmacological methods (including
breathing exercises, pulmonary rehabilitation, yoga and inspiratory muscle training) are
applied in the treatment of asthma. Exercise training; it has been reported to improve
asthma symptoms, quality of life, exercise capacity, bronchial hyperresponsiveness,
exercise-induced bronchoconstriction and cardiopulmonary fitness and reduce airway
inflammation and nighttime symptoms in asthmatic patients. In addition, asthma control
can be increased with appropriate timing and intensity of exercise-based PR. The
physiological effect of inspiratory muscle training is to weaken the metaboreflex
mechanism, possibly reducing the activity of chemosensitive afferents and sympathetic
nerve stimulation. Inspiratory muscle training stimulates structural and biochemical
adaptations within the inspiratory muscles. It is stated in the literature that
physiotherapy approaches such as breathing exercises and respiratory muscle training
provide clinical benefits by increasing inspiratory muscle strength and reducing symptoms
and the need for bronchodilators.
In recent years, the role of lncRNAs has also been emphasized in studies conducted on
asthma patients. LncRNAs are long non-coding RNAs and there are studies indicating that
they play an important role in the regulation of asthma. However, there is no study in
the literature examining the effect of exercise training on lncRNA MALAT1 in asthmatic
patients. The research is a preliminary study for further studies in this field.Asthma is
the most common chronic respiratory disease worldwide, characterized by inflammation in
the respiratory tract accompanied by bronchoconstriction, edema, and increased mucosa.
Oxidative stress causes smooth muscle contraction, proliferation, and hypersensitivity of
the airways, while hypoxia and systemic inflammation weaken the respiratory muscles. Lung
hyperinflation in asthmatic patients causes an increase in the work of breathing. The
increased workload on the respiratory muscles increases the respiratory frequency and
causes dyspnea.
Pharmacological agents, allergen avoidance, lifestyle modification, anti-IgE antibodies
and selectively alternative/complementary drugs or non-pharmacological methods (including
breathing exercises, pulmonary rehabilitation, yoga and inspiratory muscle training) are
applied in the treatment of asthma. Exercise training; it has been reported to improve
asthma symptoms, quality of life, exercise capacity, bronchial hyperresponsiveness,
exercise-induced bronchoconstriction and cardiopulmonary fitness and reduce airway
inflammation and nighttime symptoms in asthmatic patients. In addition, asthma control
can be increased with appropriate timing and intensity of exercise-based PR. The
physiological effect of inspiratory muscle training is to weaken the metaboreflex
mechanism, possibly reducing the activity of chemosensitive afferents and sympathetic
nerve stimulation. Inspiratory muscle training stimulates structural and biochemical
adaptations within the inspiratory muscles. It is stated in the literature that
physiotherapy approaches such as breathing exercises and respiratory muscle training
provide clinical benefits by increasing inspiratory muscle strength and reducing symptoms
and the need for bronchodilators.
In recent years, the role of lncRNAs has also been emphasized in studies conducted on
asthma patients. LncRNAs are long non-coding RNAs and there are studies indicating that
they play an important role in the regulation of asthma. However, there is no study in
the literature examining the effect of exercise training on lncRNA MALAT1 in asthmatic
patients. The research is a preliminary study for further studies in this field.
