ICP-332 in Subjects with Moderate to Severe Atopic Dermatitis

Inclusion Criteria:

1. Male or female subjects between 18 and 75 years of age.

2. Clinical diagnosis of chronic atopic dermatitis (also known as atopic eczema) for atleast 1 year

3. Documented recent history of inadequate response to TCS or TCI, or for whom topicaltreatments are otherwise medically inadvisable.

4. Subjects must meet the following criteria for disease activity:

• Eczema Area and Severity Index (EASI) score ≥ 16 ;

• (Body Surface Area )BSA affected by AD ≥ 10% ;

• (validated Investigator's Global Assessment-AD)vIGA-AD score ≥3 ;

• Baseline weekly average of daily Worst Pruritus NRS ≥ 4.

5. Women of childbearing potential (WOCBP) and Men must agree

6. Women of childbearing potential (WOCBP) and Men must agree to contraception. 6.Willing and able to comply with scheduled visits, treatment plan, laboratory tests,and other study procedures.

Exclusion Criteria:

1. Lack of response or inadequate response to prior treatment with any JAK inhibitorfor AD.

2. Other active skin diseases or skin infections requiring systemic treatment or wouldinterfere with appropriate assessment of atopic dermatitis lesions.

3. Pregnant or breastfeeding females.

4. History of any clinically major diseases, with the exception of atopic dermatitis.

5. Consideration by the Investigator, for any reason, that the subject is an unsuitablecandidate to receive ICP-332 or participate in this study.