Phase III Trial of Susu Zhike Granules in Children With Cold-cough Syndrome for Acute Cough Treatment

Inclusion Criteria:

1. It met the diagnostic criteria for common cold, and the severity VAS score of day ornight cough was ≥40 mm ，the cough symptom score was ≥2 points;

2. Conforming to the standard of wind-cold cough differentiation;

3. Age 6-13 years old (6 years old ≤ age < 14 years old);

4. Duration of cough ≤48 hours;

5. Maximum axillary temperature ≤38℃ within 24 hours before diagnosis;

6. The informed consent process should be in accordance with the regulations, and thelegal guardian or the subject child (≥8 years old) should sign the informed consent.

Exclusion Criteria:

1. accompanied by pharyngeal swelling pain, heat image is obvious;

2. White blood cell count, neutrophils absolute value, C-reactive protein, all exceededthe upper limit of 1.2 times the reference value, and the researchers considered thebacterial infection;

3. there have been complications (bacterial otitis media, sinusitis, suppurativetonsillitis, bronchitis, bronchopneumonia);

4. Patients with acute bronchitis and pneumonia cured less than 8 weeks;

5. People with a history of seasonal or perennial allergic rhinitis, chronic sinusitis,chronic otitis media, bronchial asthma, chronic cough or recurrent respiratoryinfections;

6. Other acute episodes of nasal diseases (vasomotor rhinitis, drug rhinitis, etc.),nasal foreign body, or foreign body inhalation, any anatomical respiratoryabnormalities;

7. Patients with serious systemic diseases or mental disorders such as cardiovascular,brain, liver, kidney and hematopoietic system;

8. Those who had used Chinese and Western drugs and therapies that had influence on theeffectiveness evaluation of the experimental drugs within 24 h before enrollment;

9. Allergic to known components of the investigational drug;

10. Those who participated in other clinical trials and took investigational drugswithin the past one month;

11. Those who were not considered suitable for inclusion by the researchers.