FARAPULSE™ Pulsed Field Ablation System

Inclusion Criteria:

1. Subjects intended to be treated with the FARAPULSE™ Pulsed Field Ablation system forcardiac tissue ablation, per physician's medical judgement, and as per hospitals'standard of care

2. Subjects who are willing and capable of providing informed consent

3. Subjects who are willing and capable of participating in all testing associated withthis clinical study at an approved clinical investigational center

4. Subjects whose age is 18 years or above.

Exclusion Criteria:

1. Subjects with a current interatrial baffle or patch

2. Subjects with a known or suspected atrial myxoma

3. Subjects with a myocardial infarction within 14 days prior to enrollment

4. Subjects with a recent (within 30 days prior to enrollment) Cerebral VascularAccident (CVA)

5. Subjects who do not tolerate anticoagulation therapy

6. Subjects with an active systemic infection *

7. Subjects with a presence of atrial known thrombus *

8. Subjects with a known inability to obtain vascular access

9. Subjects who are pregnant or planning to be pregnant

10. Subjects with atrial fibrillation that is secondary to electrolyte imbalance,thyroid disease, alcohol, or other reversible / non-cardiac causes

11. Subjects with any prosthetic heart valve, ring or repair including balloon aorticvalvuloplasty

12. Subjects with a contraindication to an invasive electrophysiology procedure whereinsertion or manipulation of a catheter in the cardiac chambers is deemed unsafe perphysician's medical judgement, such as, but not limited to, a recent previouscardiac surgery (e.g., ventriculotomy or atriotomy, CABG, PTCA/PCI/coronary stentprocedure), recent previous unstable angina and/or in patients with congenital heartdisease where the underlying abnormality increases the risk of the ablation (e.g.,severe rotational anomalies of the heart or great vessels)

13. Subjects with a life expectancy of ≤ 1 year per investigator's opinion

14. Subjects who are currently enrolled in another investigational study or registrythat would directly interfere with the current study, except when the subject isparticipating in a mandatory governmental registry, or a purely observationalregistry with no associated treatments. Each instance must be brought to theattention of the sponsor to determine eligibility.