The Intervention Effect and Potential Neural Mechanisms of Music Therapy in Children and Adolescents with Mood Disorders

Last updated: December 25, 2024
Sponsor: Shanghai Mental Health Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Affective Disorders

Mood Disorders

Treatment

conventional treatment plus music intervention

conventional treatment

Clinical Study ID

NCT06756698
2024-07
  • Ages 12-18
  • All Genders

Study Summary

This study plans to combine questionnaires, scales, electrophysiological and neuroimaging methods to comprehensively evaluate the effectiveness of music therapy for children and adolescents with emotional disorders and NSSI, and explore the potential neural mechanisms of its effectiveness.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Right-handed;

  • Born and raised in China, with Chinese as the only native language;

  • Voluntary participation, with the consent of the family members of patients under 18years old, and signed the informed consent form;

  • Meet the diagnostic criteria of DSM-5 anxiety disorder or depressive disorder;

  • There have been two or more self-harm behaviors in the past six months.

Exclusion

Exclusion Criteria:

  • Meet the diagnostic criteria of DSM-5 psychotic disorder, manic episode, autismspectrum disorder, mental retardation, tic disorder, substance abuse and othermental illnesses;

  • Severe organic brain disease;

  • Hearing loss or loss of music-related pleasure;

  • Those who have clear suicidal ideation, attempt and behavior in the past month.

Study Design

Total Participants: 54
Treatment Group(s): 2
Primary Treatment: conventional treatment plus music intervention
Phase:
Study Start date:
July 31, 2024
Estimated Completion Date:
March 31, 2026

Study Description

The subjects will be randomly divided into the conventional treatment group (TAU) and the music therapy group (MT). The conventional treatment group will receive DBT group therapy 5 times a week, 1 hour each time, and individual personalized therapy twice a week; the music therapy group will receive individual music therapy twice a week, 30 minutes each time, for a total of 3 weeks on top of conventional treatment.

During each intervention, near-infrared brain functional imaging, electrodermal and electrocardiographic equipment will be used to synchronously collect multimodal data from therapists and patients. The heart rate variability, electrodermal conductance response of therapists and patients, and the relative concentrations of oxygenated hemoglobin (oxy-Hb), deoxyhemoglobin (deoxy-Hb) and total hemoglobin in the brain tissue of the subjects and therapists were monitored during the treatment process.

Connect with a study center

  • Shanghai Mental Health Center

    Shanghai, Shanghai
    China

    Active - Recruiting

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