Effects of Cognitive Behavioral Therapy Through a Mobile App on Patients With Refractory Functional Dyspepsia

Inclusion Criteria:

1. Age 18-80

2. Refractory functional dyspepsia (patients with Rome IV functional dyspepsia remainedsymptomatic after treatment of 8 weeks of proton pump inhibitor and 4 weeks ofprokinetics)

3. Negative or unrelated-to-FD symptom findings of gastroscopy, upper abdominalultrasound, Hp test and routine blood tests within the past 1 year.

Exclusion Criteria:

1. Severe mental illness (PHQ-9 ≥20 or GAD-7 ≥15) or suicidal ideation;

2. Known hp infection, active gastrointestinal peptic ulcer, cholecystitis, gallstones,suspected or known bowel obstruction, gastroparesis, major gastrointestinal surgeryetc.;

3. Known or suspected malignant tumor, significant heart/brain/liver/kidney diseases,obvious hematologic abnormalities or endocrine diseases etc., which may be -relatedto FD symptoms;

4. Known or suspected drug-related FD (e.g.NSAIDs-related FD);

5. Unable to access to mobile networks or unable to manage mobile APP properly.

6. Allergy or other contradictions to flupenthixol or melitracen

7. Taking any antipsychotics drugs or CBT interference within 12 weeks

8. Pregnant or lactating women;

9. Unable to provide informed consent.