Effect of Preoperative Intrathecal Dexamethasone Versus Dexmedetomidine on Paralytic Ileus After Major Abdominal Surgery

Last updated: December 22, 2024
Sponsor: Assiut University
Overall Status: Active - Not Recruiting

Phase

4

Condition

Ileus

Bowel Dysfunction

Gastroparesis

Treatment

Dexmedetomidine

Dexamethasone

Clinical Study ID

NCT06752317
dexamethasone vsdexmedetomidin
  • Ages 18-60
  • All Genders

Study Summary

Postoperative Ileus (POI) is considered as intolerance of oral intake due to disruption of the normal coordinated propulsive motor activity of the gastrointestinal (GI) tract following abdominal or non-abdominal surgery.

Dexamethasone & Dexmedetomidine have been reported to attenuate the incidence of paralytic ileus after abdominal surgeries.

Previous study has shown that a single dose of DM before induction of anesthesia may be beneficial to reduce ileus for IBD by alleviating the postoperative systemic inflammatory response.

Perioperative dexmedetomidine in major abdominal surgeries significantly decreased the time to flatus, defecation, and resuming normal diet, shortened length of stay, and improved haemodynamic stability.

The aim of this study is to compare the effect of preoperative intrathecal dexamethasone versus dexmedetomidine on paralytic ileus after major abdominal surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • • Age: 18-60 years.

  • Sex: both males and females.

  • ASA physical status: I and II.

  • Operation: Open major abdominal surgery.

  • The surgery has to involve gastrointestinal resection and/or anastomosis.

Exclusion

Exclusion Criteria:

  • • History of abnormal bowl habit or bowel obstruction

  • Allergy to dexamethasone or dexmedetomidine

  • Electrolyte disturbance

  • Patient who receive any drugs known to influence gastrointestinal motility.

  • Mental disorders or inability to cooperate

  • Morbid obesity (BMI > 40), pregnancy, lactation

  • Diabetes

  • After neoadjuvant chemotherapy.

  • History of use of any steroids within the last 3 months

  • Previous abdominal surgery, herniorrhaphy or unplanned secondary surgery

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Dexmedetomidine
Phase: 4
Study Start date:
January 01, 2025
Estimated Completion Date:
March 01, 2026

Study Description

Postoperative Ileus (POI) is considered as intolerance of oral intake due to disruption of the normal coordinated propulsive motor activity of the gastrointestinal (GI) tract following abdominal or non-abdominal surgery.

Dexamethasone & Dexmedetomidine have been reported to attenuate the incidence of paralytic ileus after abdominal surgeries.

Previous study has shown that a single dose of DM before induction of anesthesia may be beneficial to reduce ileus for IBD by alleviating the postoperative systemic inflammatory response.

Perioperative dexmedetomidine in major abdominal surgeries significantly decreased the time to flatus, defecation, and resuming normal diet, shortened length of stay, and improved haemodynamic stability.