DAANCE for CHEMOTHERAPY-INDUCED NEUROPATHY

Last updated: March 13, 2025
Sponsor: Ohio State University Comprehensive Cancer Center
Overall Status: Active - Recruiting

Phase

2

Condition

Effects Of Chemotherapy

Neuropathy

Treatment

Tango

Clinical Study ID

NCT06749210
OSU-24277
OSU-24277
R01AG084676
  • Ages > 40
  • All Genders

Study Summary

Up to 80% of breast cancer survivors experience chemotherapy-induced neuropathy that impairs quality of life and increases fall risk long into survivorship, yet treatment options for neuropathy remain limited. The successful treatment will target neurophysiologic mechanisms for restoring function while addressing patient-reported symptoms and participation in treatment. Toward this end, the investigators propose to study a noninvasive, social sensorimotor intervention - Adapted Argentine Tango - which targets motor control restoration, symptom alleviation, and treatment participation in concert.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Breast Cancer (BC) diagnosis of Stage I-IV including metastatic disease

  • completed taxane-based chemotherapy for BC at least 3 months ago (no limit on howlong ago)

  • symptomatic for chemotherapy-induced neuropathy (self-report)

  • postural control score that indicates potential fall-risk

  • able to understand and comply with directions associated with testing and studytreatments

Exclusion

Exclusion Criteria:

  • pre-existing vestibular dysfunction

  • poorly controlled diabetes (hgA1C>=8)

  • non-ambulatory (assistive and prosthetic devices allowed)

  • hearing impairment resulting in less than 10% hearing bilaterally

  • contraindication to participate in the experimental physical activity per thetreating oncologist due to additional condition (e.g., herniated disc, unstable bonemetastases)

  • currently in activity-based therapy (e.g., physical therapy, occupational therapy).May enroll if still meet eligibility criteria once activity-based therapy iscomplete.

Study Design

Total Participants: 140
Treatment Group(s): 1
Primary Treatment: Tango
Phase: 2
Study Start date:
February 19, 2025
Estimated Completion Date:
August 15, 2025

Study Description

This study will investigate a noninvasive, social, sensorimotor intervention which targets motor control restoration, symptom alleviation, and treatment participation in concert: partnered Adapted Argentine Tango (Tango). This project will expand the investigators' pilot work (R21-AG068831) into a multicenter clinical trial designed to investigate the effect of social dance on sensory relief, functional restoration, and key mechanisms of action among a diverse cohort of BC survivors suffering from chronic chemotherapy-induced sensorimotor deficits.

Connect with a study center

  • The Ohio State University

    Columbus, Ohio 43220
    United States

    Active - Recruiting

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