Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease

Last updated: May 7, 2025
Sponsor: Vertex Pharmaceuticals Incorporated
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06747572
VX24-KDO-901
  • Ages 12-65
  • All Genders

Study Summary

The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 30milliliter per minute (mL/min)/1.73 m^2

  • Willing and able to comply with scheduled visits and other study procedures

  • A pre-existing diagnosis of ADPKD as defined in the protocol

Exclusion

Key Exclusion Criteria:

  • History of kidney disease other than ADPKD that in the opinion of the investigatorwould independently impact the natural history of ADPKD

  • History of solid organ or bone marrow transplantation or nephrectomy

  • Ongoing renal replacement therapy or planning to start renal replacement therapyless than or equal to (≤)12 months from the Genotyping Visit in Part A

Other protocol defined Inclusion/Exclusion criteria will apply.

Study Design

Total Participants: 400
Study Start date:
December 19, 2024
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Universitaire Ziekenhuizen Leuven

    Leuven,
    Belgium

    Active - Recruiting

  • Hopital de la Cavale Blanche

    Brest,
    France

    Active - Recruiting

  • Necker Hospital

    Paris,
    France

    Active - Recruiting

  • FDI Clinicial Research

    San Juan,
    Puerto Rico

    Active - Recruiting

  • King's College Hospital

    London,
    United Kingdom

    Active - Recruiting

  • Royal Free NHS Trust

    London,
    United Kingdom

    Active - Recruiting

  • Sheffield Kidney Institute, Northern General Hospital

    Sheffield,
    United Kingdom

    Active - Recruiting

  • Alabama Kidney Research

    Alabaster, Alabama 35007
    United States

    Active - Recruiting

  • Kaiser Permanente - Los Angeles Medical Center

    Los Angeles, California 90027
    United States

    Active - Recruiting

  • DaVita Clinical Research

    Middlebury, Connecticut 06762
    United States

    Active - Recruiting

  • Yale Nephrology Clinical Research Clinic

    New Haven, Connecticut 06510
    United States

    Active - Recruiting

  • Nature Coast Clinical Research - Inverness

    Inverness, Florida 34452
    United States

    Active - Recruiting

  • Emory School of Medicine - Renal Division

    Atlanta, Georgia 30308
    United States

    Active - Recruiting

  • Renal Associates, LLC

    Columbus, Georgia 31904
    United States

    Active - Recruiting

  • University of Iowa Hospital & Clinics

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

  • University of Kansas Medical Center

    Kansas City, Kansas 66160
    United States

    Active - Recruiting

  • Tufts Medical Center

    Boston, Massachusetts 02111
    United States

    Active - Recruiting

  • Quest Research Institute

    Farmington Hills, Michigan 48334
    United States

    Active - Recruiting

  • DaVita Clinical Research

    Las Vegas, Nevada 89107
    United States

    Active - Recruiting

  • Columbia University Medical Center

    New York, New York 10032
    United States

    Active - Recruiting

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