Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease

Last updated: February 10, 2026
Sponsor: Vertex Pharmaceuticals Incorporated
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06747572
VX24-KDO-901
NL88429.078.24
  • Ages 12-65
  • All Genders

Study Summary

The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 30milliliter per minute (mL/min)/1.73 m^2

  • Willing and able to comply with scheduled visits and other study procedures

  • A pre-existing diagnosis of ADPKD as defined in the protocol

Exclusion

Key Exclusion Criteria:

  • History of kidney disease other than ADPKD that in the opinion of the investigatorwould independently impact the natural history of ADPKD

  • History of solid organ or bone marrow transplantation or nephrectomy

  • Ongoing renal replacement therapy or planning to start renal replacement therapyless than or equal to (≤)12 months from the Genotyping Visit in Part A

Other protocol defined Inclusion/Exclusion criteria will apply.

Study Design

Total Participants: 401
Study Start date:
December 19, 2024
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Universite Catholique de Louvain, Cliniques universitaires Saint-Luc (UCLouvain)

    Brussels,
    Belgium

    Site Not Available

  • Universite Catholique de Louvain, Cliniques universitaires Saint-Luc (UCLouvain)

    Brussels 2800866,
    Belgium

    Site Not Available

  • Universitaire Ziekenhuizen Leuven

    Leuven,
    Belgium

    Site Not Available

  • Universitaire Ziekenhuizen Leuven

    Leuven 2792482,
    Belgium

    Site Not Available

  • St. Joseph's Healthcare - Hamilton

    Hamilton,
    Canada

    Site Not Available

  • St. Joseph's Healthcare - Hamilton

    Hamilton 5969782,
    Canada

    Site Not Available

  • McGill University Health Centre, Glen Site

    Montreal,
    Canada

    Site Not Available

  • MUHC - Montreal Children's Hospital

    Montreal 6077243,
    Canada

    Site Not Available

  • McGill University Health Centre, Glen Site

    Montreal 6077243,
    Canada

    Active - Recruiting

  • Hopital de la Cavale Blanche

    Brest,
    France

    Site Not Available

  • Hopital de la Cavale Blanche

    Brest 3030300,
    France

    Site Not Available

  • Necker Hospital

    Paris,
    France

    Site Not Available

  • Necker Hospital

    Paris 2988507,
    France

    Site Not Available

  • Charité - Paediatric Pulmonology Department

    Berlin,
    Germany

    Site Not Available

  • Charité - Klinik für Nephrologie und Intensivmedizin der

    Berlin 2950159,
    Germany

    Site Not Available

  • Charité - Paediatric Pulmonology Department

    Berlin 2950159,
    Germany

    Active - Recruiting

  • Universitaetsklinik Koeln Department II of Internal Medicine

    Cologne,
    Germany

    Site Not Available

  • Universitaetsklinik Koeln Department II of Internal Medicine

    Cologne 2886242,
    Germany

    Site Not Available

  • UMCG - Nephrology

    Groningen,
    Netherlands

    Site Not Available

  • University Medical Center Groningen

    Groningen,
    Netherlands

    Active - Recruiting

  • UMCG - Nephrology

    Groningen 2755251,
    Netherlands

    Site Not Available

  • Erasmus Medisch Centrum - Nephrology

    Rotterdam,
    Netherlands

    Site Not Available

  • Erasmus Medisch Centrum - Nephrology

    Rotterdam 2747891,
    Netherlands

    Site Not Available

  • FDI Clinicial Research

    San Juan,
    Puerto Rico

    Site Not Available

  • FDI Clinical Research - San Juan

    San Juan 4568127,
    Puerto Rico

    Site Not Available

  • FDI Clinicial Research

    San Juan 4568127,
    Puerto Rico

    Site Not Available

  • Hospital Fundacion Jimenez Diaz

    Madrid,
    Spain

    Site Not Available

  • Hospital Fundacion Jimenez Diaz

    Madrid 3117735,
    Spain

    Site Not Available

  • Queen Elizabeth Hospital Birmingham

    Birmingham 2655603,
    United Kingdom

    Site Not Available

  • King's College Hospital

    London,
    United Kingdom

    Active - Recruiting

  • Royal Free NHS Trust

    London,
    United Kingdom

    Active - Recruiting

  • St Georges University Hospitals NHS Foundation Trust

    London,
    United Kingdom

    Site Not Available

  • King's College Hospital

    London 2643743,
    United Kingdom

    Site Not Available

  • Royal Free NHS Trust

    London 2643743,
    United Kingdom

    Site Not Available

  • St Georges University Hospitals NHS Foundation Trust

    London 2643743,
    United Kingdom

    Site Not Available

  • Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital - Nephrology

    Newcastle Upon Tyne,
    United Kingdom

    Site Not Available

  • Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital - Nephrology

    Newcastle upon Tyne 2641673,
    United Kingdom

    Site Not Available

  • Northern General Hospital

    Sheffield,
    United Kingdom

    Site Not Available

  • Sheffield Kidney Institute, Northern General Hospital

    Sheffield,
    United Kingdom

    Active - Recruiting

  • Northern General Hospital

    Sheffield 2638077,
    United Kingdom

    Site Not Available

  • Alabama Kidney Research

    Alabaster, Alabama 35007
    United States

    Site Not Available

  • Alabama Kidney Research

    Alabaster 4829762, Alabama 4829764 35007
    United States

    Site Not Available

  • The Kirklin Clinic - Nephrology

    Birmingham 4049979, Alabama 4829764 35294
    United States

    Active - Recruiting

  • University of Alabama at Birmingham- Nephrology Research Clinic

    Birmingham 4049979, Alabama 4829764 35294
    United States

    Site Not Available

  • Kaiser Permanente - Los Angeles Medical Center

    Los Angeles, California 90027
    United States

    Active - Recruiting

  • UCLA Division of Nephrology

    Los Angeles, California 90095
    United States

    Site Not Available

  • Helen Diller Medical Center at Parnassus Heights

    San Francisco, California 94143
    United States

    Site Not Available

  • Kaiser Permanente - Los Angeles Medical Center

    Los Angeles 5368361, California 5332921 90027
    United States

    Site Not Available

  • UCLA Division of Nephrology

    Los Angeles 5368361, California 5332921 90095
    United States

    Site Not Available

  • Helen Diller Medical Center at Parnassus Heights

    San Francisco 5391959, California 5332921 94143
    United States

    Site Not Available

  • DaVita Clinical Research

    Middlebury, Connecticut 06762
    United States

    Active - Recruiting

  • Nephrology & Hypertension Associates, PC

    Middlebury, Connecticut 06762
    United States

    Site Not Available

  • Yale Nephrology Clinical Research Clinic

    New Haven, Connecticut 06510
    United States

    Site Not Available

  • Nephrology & Hypertension Associates, PC

    Middlebury 4838611, Connecticut 4831725 06762
    United States

    Site Not Available

  • Yale Nephrology Clinical Research Clinic

    New Haven 4839366, Connecticut 4831725 06510
    United States

    Site Not Available

  • Nature Coast Clinical Research - Inverness

    Inverness, Florida 34452
    United States

    Site Not Available

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • Nature Coast Clinical Research - Inverness

    Inverness 4159786, Florida 4155751 34452
    United States

    Site Not Available

  • Mayo Clinic - Jacksonville

    Jacksonville 4160021, Florida 4155751 32224
    United States

    Site Not Available

  • Emory School of Medicine - Renal Division

    Atlanta, Georgia 30308
    United States

    Site Not Available

  • Renal Associates, LLC

    Columbus, Georgia 31904
    United States

    Site Not Available

  • Emory School of Medicine - Renal Division

    Atlanta 4180439, Georgia 4197000 30308
    United States

    Site Not Available

  • Renal Associates, LLC

    Columbus 4188985, Georgia 4197000 31904
    United States

    Site Not Available

  • UChicago Medicine - Duchossois Center for Advanced Medicine - Nephrology

    Chicago, Illinois 60637
    United States

    Site Not Available

  • UChicago Medicine - Duchossois Center for Advanced Medicine - Nephrology

    Chicago 4887398, Illinois 4896861 60637
    United States

    Site Not Available

  • University of Iowa Hospital & Clinics

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • University of Iowa Health Care Medical Center- Nephrology

    Iowa City 4862034, Iowa 4862182 52242
    United States

    Site Not Available

  • University of Iowa Hospital & Clinics

    Iowa City 4862034, Iowa 4862182 52242
    United States

    Active - Recruiting

  • University of Kansas Medical Center

    Kansas City, Kansas 66160
    United States

    Site Not Available

  • University of Kansas Medical Center

    Kansas City 4273837, Kansas 4273857 66160
    United States

    Site Not Available

  • General Clinical Research Center, University of Maryland Baltimore

    Baltimore, Maryland 21201
    United States

    Site Not Available

  • General Clinical Research Center, University of Maryland Baltimore

    Baltimore 4347778, Maryland 4361885 21201
    United States

    Site Not Available

  • Beth Israel Deaconess Medical Center - Nephrology

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Tufts Medical Center

    Boston, Massachusetts 02111
    United States

    Active - Recruiting

  • Beth Israel Deaconess Medical Center - Nephrology

    Boston 4930956, Massachusetts 6254926 02215
    United States

    Site Not Available

  • Tufts Medical Center

    Boston 4930956, Massachusetts 6254926 02111
    United States

    Site Not Available

  • Quest Research Institute

    Farmington Hills, Michigan 48334
    United States

    Site Not Available

  • Quest Research Institute

    Farmington Hills 4992523, Michigan 5001836 48334
    United States

    Site Not Available

  • Mayo Clinic - Rochester

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • University of Minnesota -Health Clinical Research Unit

    Minneapolis 5037649, Minnesota 5037779 55455
    United States

    Site Not Available

  • Mayo Clinic - Rochester

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Site Not Available

  • DaVita Clinical Research

    Las Vegas, Nevada 89107
    United States

    Site Not Available

  • DaVita Clinical Research

    Las Vegas 5506956, Nevada 5509151 89107
    United States

    Site Not Available

  • Columbia University Medical Center

    New York, New York 10032
    United States

    Site Not Available

  • Columbia University Medical Center

    New York 5128581, New York 5128638 10032
    United States

    Site Not Available

  • Perelman Center for Advanced Medicine - Nephrology

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Geisinger Clinic

    Danville 5186327, Pennsylvania 6254927 17822
    United States

    Site Not Available

  • Perelman Center for Advanced Medicine - Nephrology

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Site Not Available

  • Nephrology Clinical Trials Center

    Nashville 4644585, Tennessee 4662168 37232
    United States

    Site Not Available

  • UVM Medical Center - 1 South Prospect Street

    Burlington, Vermont 05401
    United States

    Site Not Available

  • UVM Medical Center - 1 South Prospect Street

    Burlington 5234372, Vermont 5242283 05401
    United States

    Site Not Available

  • Swedish Center for Comprehensive Care

    Seattle, Washington 98104
    United States

    Site Not Available

  • Swedish Center for Comprehensive Care

    Seattle 5809844, Washington 5815135 98104
    United States

    Site Not Available

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