Fast Discharge After Acute Myocardial Infarction Discharge MI

Last updated: December 19, 2024
Sponsor: Medical University Innsbruck
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cardiac Disease

Circulation Disorders

Heart Attack (Myocardial Infarction)

Treatment

Fast discharge strategy

Clinical Study ID

NCT06744322
1284/2024
20241113-3609
  • Ages > 18
  • All Genders

Study Summary

To evaluate the hypothesis that a fast discharge strategy (discharge at 24 [± 12] hours) following invasive management for acute myocardial infarction is non-inferior to standard of care (72 [± 24] hours) with respect to the risk of major adverse cardiovascular events (MACE) at 12 months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Uncomplicated acute myocardial infarction (NSTEMI and STEMI) diagnosed according tothe 2023 acute coronary syndrome guidelines of the ESC

  • Age ≥ 18 years at time of consent

  • Invasive management strategy and in case of PCI successful intervention of theculprit lesion defined by post-interventional TIMI 3 flow

  • Absence of PCI-related complications (coronary perforation, side branch closure,inability to deliver stent/balloon, aortic dissection, allergic reaction grade ≥2,stroke/thromboembolism, access site complications including pseudoaneurysm,arteriovenous fistula, retroperitoneal hemorrhage and arterial dissection/occlusionor emboli)

  • Ability to understand and willingness to sign and date written informed consent

Exclusion

Exclusion Criteria:

  • Myocardial infarction complicated by cardiac arrest (out-of-hospital cardiacarrest/in-hospital cardiac arrest)

  • Malignant arrhythmias including sustained ventricular arrhythmias and persistentbradycardia (< 50 beats per minute due to sinus node or atrioventricular conductionsystem abnormalities, second- /third-degree atrioventricular block) after PCI

  • Ongoing hemodynamic instability (systolic blood pressure <90 mmHg, elevated lactateconcentrations, need for inotropes or vasopressors)

  • Ongoing respiratory instability defined by Killip class >I (rales, pulmonary edema)

  • Ongoing quantitative disorders of consciousness (somnolence, sopor, coma)

  • Pregnancy

  • Immobility/limited mobility or social circumstances that prevent fast dischargeassessed by an interprofessional care team

Study Design

Total Participants: 2224
Treatment Group(s): 1
Primary Treatment: Fast discharge strategy
Phase:
Study Start date:
December 01, 2024
Estimated Completion Date:
December 31, 2029

Study Description

The goal of this randomized, multicenter trial is to assess the safety of a fast discharge strategy following acute myocardial infarction as compared to standard of care. The trial will evaluate the hypothesis that a fast discharge strategy (discharge at 24 [± 12] hours) following invasive management of acute myocardial infarction is non-inferior to standard of care (discharge at 72 [± 24] hours) with respect to the risk of major adverse cardiovascular events at 12 months.

Connect with a study center

  • Hospital Wiener Neustadt

    Wiener Neustadt, Niederösterreich 2700
    Austria

    Site Not Available

  • University Teaching Hospital Wels-Grieskirchen

    Wels, Oberösterreich 4600
    Austria

    Site Not Available

  • Medical University of Graz

    Graz, Steiermark 8010
    Austria

    Site Not Available

  • Medical University of Innsbruck

    Innsbruck, Tyrol 6020
    Austria

    Active - Recruiting

  • Academic Teaching Hospital Feldkirch

    Feldkirch, Vorarlberg 6800
    Austria

    Site Not Available

  • Paracelsus Medical University Salzburg

    Salzburg, 5020
    Austria

    Site Not Available

  • Cardinal Schwarzenberg Hospital Schwarzach

    Schwarzach im Pongau, 5620
    Austria

    Site Not Available

  • Ludwig Maximilian University Munich

    Munich, Bayern 81377
    Germany

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.