Trazodone on NREM Sleep Stage Ⅲ in Depressed Insomniac Co-morbid Patients

Inclusion Criteria:

• Outpatient or inpatient patients;

• 18 years old ≤ 65 years old;

• Simultaneously meet the diagnostic criteria for depression and non organic insomniain the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in the United States;

• 17 items of Hamilton Depression Rating Scale (HAMD-17) with a total score of ≥ 17points;

• Pittsburgh Sleep Quality Index (PSQI) ≥ 16 points;

• Never used related antidepressants and sedative hypnotic drugs;

• Has a certain level of visual and auditory resolution, and no comprehensionbarriers;

• Capable of independently completing scale measurements;

• Education level above primary school;

• Obtain written informed consent from the patient, and obtain written informedconsent from the legal guardian if the patient is incapacitated during the onset ofthe illness.

Exclusion Criteria:

• Patients with comorbidities such as schizophrenia, schizophrenia, bipolar disorder,mental retardation, pervasive developmental disorder, delirium, dementia, cognitiveimpairment, alcohol dependence, etc

• Suffering from serious organic diseases, such as diabetes, thyroid disease,hypertension, cardiovascular disease, craniocerebral trauma, cerebral ischemia orhemorrhage;

• Patients with narrow angle glaucoma;

• History of epilepsy and febrile seizures;

• Individuals with a history of drug use;

• Positive for syphilis specific antibody and AIDS antibody;

• According to risk assessment, there are currently serious suicide attempts orindividuals who are overly agitated Pregnant or lactating women, or those planningto conceive in the near future;

• Laboratory tests indicate the presence of liver and kidney function impairment inindividuals;

• There are other individuals who meet the relevant contraindications forantidepressants.