The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR

Last updated: December 16, 2024
Sponsor: National Cheng-Kung University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Neuromuscular Electrical Stimulation

blood flow restriction

Low Level Laser Therapy

Clinical Study ID

NCT06739148
A-ER-113-089
  • Ages 20-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Healthy adults aged 20-40, without a diagnosis of cardiovascular orneuromusculoskeletal diseases.

  2. Normal vision range after visual correction.

Exclusion

Exclusion Criteria:

  1. Exclude students who have a teacher-student relationship with the principalinvestigator to ensure the participants' autonomy.

  2. History of brain injury, stroke, spinal cord injury, or other neuromuscular-relatedconditions.

  3. Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleedingareas, and photosensitive skin regions.

  4. Presence of any contraindications for blood flow restriction training, such as ahistory of injury or strain in the non-dominant arm's biceps, deep veinthrombosis or venous occlusion in the non-dominant arm, acute unstable fractures inthe non-dominant arm, acute regional infections in the non-dominant arm, severeperipheral arterial occlusive disease in the non-dominant arm, complete lymphaticobstruction in the non-dominant arm, and edema due to acute pulmonary edema orcongestive heart failure in the non-dominant arm.

Study Design

Total Participants: 44
Treatment Group(s): 3
Primary Treatment: Neuromuscular Electrical Stimulation
Phase:
Study Start date:
October 01, 2024
Estimated Completion Date:
July 31, 2025

Connect with a study center

  • National Chen Kong University Hospital, Tainan

    Tainan,
    Taiwan

    Active - Recruiting

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