An Open-Label Study to Assess the Long-term Safety of AXS-05 in Subjects With Dementia of the Alzheimer's Type, ADVANCE-2 and ACCORD-2 Extension Study

Inclusion Criteria:

• Completed the treatment period in Study AXS-05-AD-304 or exited from StudyAXS-05-AD-303 due to study completion.

• Caregiver is willing to communicate with site personnel, comply with all requiredstudy procedures, and oversee administration and compliance with the subject's studytreatment.

Exclusion Criteria:

• Caregiver is unwilling or unable, in the opinion of the Investigator, to comply withstudy instructions.

• Subject is hospitalized in a mental health facility (e.g., psychiatric hospital orward), living in a nursing home, or living alone.

• Any concurrent medical condition that might interfere with the conduct of the study,confound the interpretation of study results, or endanger the subject's well-being.

• Initiation of a new medication since enrolling in AXS-05-AD-304 and/or AXS-05-AD-303which may pose a safety risk when taken concurrently with AXS-05.