Pilot Study "AHSP as a Biomarker of Sickle Cell Disease in a Population of Adults and Children"

Inclusion Criteria:

Inclusion Criteria for Sickle Cell Patients

1. Adults: > 15 years and 6 months

2. Pediatrics: ≥ 3 years and ≤ 15 years and 6 months

3. Known SS or Sβ0 phenotypes

Inclusion Criteria for Control Patients.

1 -Adults: > 15 years and 6 months /Pediatrics: ≥ 3 years and ≤ 15 years and 6 months 2-Absence of Hemoglobinopathy 3-Follow-up for one of the following conditions (adults): Evaluation of hematological disease excluding hemoglobinopathy, evaluation of prolonged fever or inflammatory syndrome, initial or episodic evaluation of an auto-inflammatory disease or systemic disease, general health deterioration

-Follow-up for one of the following conditions (pediatrics): Suspected precocious puberty, growth delay, or neurodevelopmental disorder

4-Blood sample planned as part of medical care

Exclusion Criteria:

1. Hemoglobin disorder other than sickle cell disease (Criteria for Sickle CellPatients)

2. Hemoglobinopathies other than sickle cell disease (Criteria for Control Patients)

3. Transfusion less than 3 months ago

4. Chronic active viral disease: hepatitis B, C, HIV

5. Current infections or known inflammatory pathologies

6. Known hyper or hypothyroidism or subject treated with levothyroxine

7. Active tumor pathology or remission for less than 5 years

8. Oral corticosteroid therapy in progress

9. Participation in interventional biomedical research

10. Opposition to participation in research by the patient if he is an adult, or by oneof the two parents if the patient is a minor.

11. Non-affiliation to a social security system