The Efficacy and Safety of HRS8179 in Severe Cerebral Edema Following Large Hemispheric Infarction

Inclusion Criteria:

1. Fully understand and voluntarily participate in this trial, and sign the informedconsent form (the informed consent form can be signed voluntarily by the participantor their legal representative);

2. A clinical diagnosis of acute ischemic stroke in the middle cerebral artery (MCA)territory;

3. National Institutes of Health Stroke Scale (NIHSS) ≥ 10 at screening;

4. A large hemispheric infarction defined as: lesion volume of 80 to 160 cm3 onmagnetic resonance imaging (MRI) diffusion-weighted imaging (DWI), or computedtomography perfusion (CTP).

5. The time from onset to treatment must be ≤ 10 hours; if the onset time is unknown,treatment must be initiated within 10 hours after the time last known normal.

Exclusion Criteria:

1. Theparticipant is likely to withdraw the supportive treatment on the first day;

2. There is evidence indicating a concurrent infarction in the contralateral hemispheresufficiently serious to affect functional outcome.

3. There are clinical signs of brain herniation; CT/MRI indicates a midline shift of >2mm; CT/MRI indicates cerebral hemorrhage;