Human Umbilical Cord Mesenchymal Stem Cells for Alport Syndrome

Inclusion Criteria:

• 3 years old ≤Age ≤ 12 years old;

• Meet the diagnostic criteria of Alport syndrome;

• Positive proteinuria or combined hematuria;

• Chronic kidney disease (CKD) stage: I-III stage children, that is, glomerularfiltration rate greater than 60 ml/min.1.73m2;

• No history of infectious diseases within 1 week before treatment;

• Negative infectious disease screening;

• No allergic state and related clinical manifestations;

• Signed informed consent (children or their families).

Exclusion Criteria:

• Age <3 years or >12 years old;

• Alport syndrome patients with only microscopic hematuria and normal glomerularfiltration rate;

• Patients with significantly reduced renal function, chronic kidney disease stage IVor V, Alport syndrome;

• Patients with other renal diseases;

• Have a history of severe allergic reactions or be allergic to 2 or more foods ordrugs;

• Known allergy to stem cells or stem cell-derived products or ingredients in stemcell preparations;

• Have severe heart, liver, lung and other organ dysfunction or have tumors;

• Those with developmental malformations of the urinary system;

• Those with autoimmune diseases and regular use of immunosuppressants;

• Those with serious infectious diseases that are not under control;

• Those with a history of infectious diseases such as HBV, HCV, HIV, syphilis;

• History of surgery or acute trauma or blood loss exceeding 200ml within 3 months;

• Participated in other clinical studies within 3 months;

• Have received any cell product or derivative product treatment within 12 months;

• Other circumstances that the researcher deems inappropriate for inclusion.