A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

Last updated: December 19, 2024
Sponsor: Pfizer
Overall Status: Active - Recruiting

Phase

2

Condition

Diabetes Prevention

Obesity

Treatment

Placebo

PF-07976016

Clinical Study ID

NCT06717425
C5541010
2024-513679-42-00
  • Ages 18-74
  • All Genders

Study Summary

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07976016) for the potential treatment of obesity. The study will compare the experiences of participants taking the study medicine (PF-07976016) to those of participants who take placebo (a lookalike substance that contains no active study medicine). The aim is to measure the body's response to the study medicine, including any changes in participants' body weight and how well they tolerate the study medicine.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Male or non-pregnant, non-breastfeeding female, 18 to 74 years of age at Visit 1

  • Body Mass Index ≥30.0 kg/m2 at Visit 1, with stable body weight, defined as <5 kgchange in the 12 weeks before Visit 1

  • Eligible and willing to receive required background medicine

  • Willing and able to comply with all study procedures

Exclusion

Key Exclusion Criteria:

  • Any medical or psychiatric condition or laboratory abnormality, or recent seriousillness or hospitalization, that may increase the risk of study participation or, inthe investigator's judgment, make the participant inappropriate for the studyincluding diagnosis of type 2 diabetes mellitus, type 1 or secondary forms ofdiabetes.

  • Use of any prohibited prior or concomitant medication(s)

  • Presence of specified abnormalities on diagnostic assessments including clinicallaboratory tests at Visit 1.

Study Design

Total Participants: 252
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 2
Study Start date:
December 09, 2024
Estimated Completion Date:
January 17, 2026

Connect with a study center

  • Milestone Research Inc.

    London, Ontario N5W 6A2
    Canada

    Site Not Available

  • Canadian Phase Onward

    Toronto, Ontario M3J 0K2
    Canada

    Site Not Available

  • Artemis Institute for Clinical Research

    San Diego, California 92103
    United States

    Site Not Available

  • Westside Center for Clinical Research

    Jacksonville, Florida 32205
    United States

    Site Not Available

  • New Horizon Research Center

    Miami, Florida 33165
    United States

    Site Not Available

  • St Johns Center for Clinical Research

    Saint Augustine, Florida 32086
    United States

    Site Not Available

  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City, Georgia 30291
    United States

    Active - Recruiting

  • East-West Medical Research Institute

    Honolulu, Hawaii 96814
    United States

    Site Not Available

  • L-MARC Research Center

    Louisville, Kentucky 40213
    United States

    Active - Recruiting

  • Rochester Clinical Research, LLC

    Rochester, New York 14609
    United States

    Site Not Available

  • Alliance for Multispecialty Research, LLC

    Norman, Oklahoma 73069
    United States

    Site Not Available

  • Cornerstone Nutrition and Diabetes

    Norman, Oklahoma 73069
    United States

    Site Not Available

  • Capital Area Research, LLC

    Camp Hill, Pennsylvania 17011
    United States

    Site Not Available

  • Elligo Clinical Research Center

    Austin, Texas 78704
    United States

    Site Not Available

  • Texas Diabetes & Endocrinology, P.A.

    Austin, Texas 78749
    United States

    Site Not Available

  • UT Southwestern Medical Center

    Dallas, Texas 75390
    United States

    Site Not Available

  • Velocity Clinical Research, Dallas

    Dallas, Texas 75230
    United States

    Site Not Available

  • Consano Clinical Research, LLC

    Shavano Park, Texas 78231
    United States

    Site Not Available

  • Chrysalis Clinical Research

    Saint George, Utah 84790
    United States

    Site Not Available

  • Southwest Internal Medicine, PC

    Saint George, Utah 84790
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.