A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

Last updated: November 19, 2025
Sponsor: Pfizer
Overall Status: Active - Not Recruiting

Phase

2

Condition

Obesity

Diabetes Prevention

Treatment

Placebo

PF-07976016

Clinical Study ID

NCT06717425
C5541010
2024-513679-42-00
  • Ages 18-74
  • All Genders

Study Summary

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07976016) for the potential treatment of obesity. The study will compare the experiences of participants taking the study medicine (PF-07976016) to those of participants who take placebo (a lookalike substance that contains no active study medicine). The aim is to measure the body's response to the study medicine, including any changes in participants' body weight and how well they tolerate the study medicine.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Male or non-pregnant, non-breastfeeding female, 18 to 74 years of age at Visit 1

  • Body Mass Index ≥30.0 kg/m2 at Visit 1, with stable body weight, defined as <5 kgchange in the 12 weeks before Visit 1

  • Eligible and willing to receive required background medicine

  • Willing and able to comply with all study procedures

Exclusion

Key Exclusion Criteria:

  • Any medical or psychiatric condition or laboratory abnormality, or recent seriousillness or hospitalization, that may increase the risk of study participation or, inthe investigator's judgment, make the participant inappropriate for the studyincluding diagnosis of type 2 diabetes mellitus, type 1 or secondary forms ofdiabetes.

  • Use of any prohibited prior or concomitant medication(s)

  • Presence of specified abnormalities on diagnostic assessments including clinicallaboratory tests at Visit 1.

Study Design

Total Participants: 263
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 2
Study Start date:
December 09, 2024
Estimated Completion Date:
November 27, 2025

Connect with a study center

  • Ocean West Research Clinic

    Surrey, British Columbia V3Z 2N6
    Canada

    Site Not Available

  • Ocean West Research Clinic

    Surrey 6159905, British Columbia 5909050 V3Z 2N6
    Canada

    Site Not Available

  • Dawson Clinical Research Inc.

    Guelph, Ontario N1H 1B1
    Canada

    Site Not Available

  • The Wharton Medical Clinic Clinical Trials Inc.

    Hamilton, Ontario L8L 5G8
    Canada

    Site Not Available

  • Milestone Research Inc.

    London, Ontario N5W 6A2
    Canada

    Site Not Available

  • Canadian Phase Onward

    Toronto, Ontario M3J 0K2
    Canada

    Site Not Available

  • Dawson Clinical Research Inc.

    Guelph 5967629, Ontario 6093943 N1H 1B1
    Canada

    Site Not Available

  • The Wharton Medical Clinic Clinical Trials Inc.

    Hamilton 5969782, Ontario 6093943 L8L 5G8
    Canada

    Site Not Available

  • Milestone Research Inc.

    London 6058560, Ontario 6093943 N5W 6A2
    Canada

    Site Not Available

  • Canadian Phase Onward

    Toronto 6167865, Ontario 6093943 M3J 0K2
    Canada

    Site Not Available

  • Centrum Zdrowia Metabolicznego Pawel Bogdanski

    Poznan 3088171, Greater Poland Voivodeship 3337498 60-589
    Poland

    Site Not Available

  • Medicome Sp. z o. o.

    Oświęcim 3089658, Lesser Poland Voivodeship 858786 32-600
    Poland

    Site Not Available

  • Ekamed

    Lublin, Lubelskie 20-718
    Poland

    Site Not Available

  • Ekamed

    Lublin 765876, Lublin Voivodeship 858785 20-718
    Poland

    Site Not Available

  • Medicome Sp. z o. o.

    Oświęcim, Małopolskie 32-600
    Poland

    Site Not Available

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    Gdansk 3099434, Pomeranian Voivodeship 3337496 80-546
    Poland

    Site Not Available

  • Centrum Medyczne Pratia Gdynia

    Gdynia 3099424, Pomeranian Voivodeship 3337496 81-338
    Poland

    Site Not Available

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    Gdansk, Pomorskie 80-546
    Poland

    Site Not Available

  • Centrum Medyczne Pratia Gdynia

    Gdynia, Pomorskie 81-338
    Poland

    Site Not Available

  • Centrum Zdrowia Metabolicznego Pawel Bogdanski

    Poznań, Wielkopolskie 60-589
    Poland

    Site Not Available

  • Anaheim Clinical Trials, LLC

    Anaheim, California 92801
    United States

    Site Not Available

  • Artemis Institute for Clinical Research

    San Diego, California 92103
    United States

    Site Not Available

  • Anaheim Clinical Trials, LLC

    Anaheim 5323810, California 5332921 92801
    United States

    Site Not Available

  • Artemis Institute for Clinical Research

    San Diego 5391811, California 5332921 92103
    United States

    Site Not Available

  • Clinical & Translational Research Center

    Aurora, Colorado 80045
    United States

    Site Not Available

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Clinical & Translational Research Center

    Aurora 5412347, Colorado 5417618 80045
    United States

    Site Not Available

  • University of Colorado Anschutz Medical Campus

    Aurora 5412347, Colorado 5417618 80045
    United States

    Site Not Available

  • Westside Center for Clinical Research

    Jacksonville, Florida 32205
    United States

    Site Not Available

  • New Horizon Research Center

    Miami, Florida 33165
    United States

    Site Not Available

  • Renstar Medical Research

    Ocala, Florida 34471
    United States

    Site Not Available

  • St Johns Center for Clinical Research

    Saint Augustine, Florida 32086
    United States

    Site Not Available

  • Westside Center for Clinical Research

    Jacksonville 4160021, Florida 4155751 32205
    United States

    Site Not Available

  • New Horizon Research Center

    Miami 4164138, Florida 4155751 33165
    United States

    Site Not Available

  • Renstar Medical Research

    Ocala 4166673, Florida 4155751 34471
    United States

    Site Not Available

  • St Johns Center for Clinical Research

    Saint Augustine 4170894, Florida 4155751 32086
    United States

    Site Not Available

  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City, Georgia 30291
    United States

    Site Not Available

  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City 4227777, Georgia 4197000 30291
    United States

    Site Not Available

  • East-West Medical Research Institute

    Honolulu, Hawaii 96814
    United States

    Site Not Available

  • East-West Medical Research Institute

    Honolulu 5856195, Hawaii 5855797 96814
    United States

    Site Not Available

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, Kansas 66606
    United States

    Site Not Available

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka 4280539, Kansas 4273857 66606
    United States

    Site Not Available

  • L-MARC Research Center

    Louisville, Kentucky 40213
    United States

    Site Not Available

  • L-MARC Research Center

    Louisville 4299276, Kentucky 6254925 40213
    United States

    Site Not Available

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana 70808
    United States

    Site Not Available

  • Pennington Biomedical Research Center

    Baton Rouge 4315588, Louisiana 4331987 70808
    United States

    Site Not Available

  • StudyMetrix Research

    Saint Peters, Missouri 63303
    United States

    Site Not Available

  • StudyMetrix Research

    City of Saint Peters 4407237, Missouri 4398678 63303
    United States

    Site Not Available

  • Rochester Clinical Research, LLC

    Rochester, New York 14609
    United States

    Site Not Available

  • Rochester Clinical Research, LLC

    Rochester 5134086, New York 5128638 14609
    United States

    Site Not Available

  • Accellacare - Wilmington

    Wilmington, North Carolina 28401
    United States

    Site Not Available

  • Accellacare - Wilmington

    Wilmington 4499379, North Carolina 4482348 28401
    United States

    Site Not Available

  • AMR Clinical

    Norman, Oklahoma 73069
    United States

    Site Not Available

  • Alliance for Multispecialty Research, LLC

    Norman, Oklahoma 73069
    United States

    Site Not Available

  • Cornerstone Nutrition and Diabetes

    Norman, Oklahoma 73069
    United States

    Site Not Available

  • AMR Clinical

    Norman 4543762, Oklahoma 4544379 73069
    United States

    Site Not Available

  • Cornerstone Nutrition and Diabetes

    Norman 4543762, Oklahoma 4544379 73069
    United States

    Site Not Available

  • Capital Area Research, LLC

    Camp Hill, Pennsylvania 17011
    United States

    Site Not Available

  • Capital Area Research, LLC

    Camp Hill 5182928, Pennsylvania 6254927 17011
    United States

    Site Not Available

  • Elligo Clinical Research Center

    Austin, Texas 78704
    United States

    Site Not Available

  • Texas Diabetes & Endocrinology, P.A.

    Austin, Texas 78749
    United States

    Site Not Available

  • UT Southwestern Medical Center

    Dallas, Texas 75390
    United States

    Site Not Available

  • Velocity Clinical Research, Dallas

    Dallas, Texas 75230
    United States

    Site Not Available

  • Consano Clinical Research, LLC

    Shavano Park, Texas 78231
    United States

    Site Not Available

  • Elligo Clinical Research Center

    Austin 4671654, Texas 4736286 78704
    United States

    Site Not Available

  • Texas Diabetes & Endocrinology, P.A.

    Austin 4671654, Texas 4736286 78749
    United States

    Site Not Available

  • UT Southwestern Medical Center

    Dallas 4684888, Texas 4736286 75390
    United States

    Site Not Available

  • Velocity Clinical Research, Dallas

    Dallas 4684888, Texas 4736286 75230
    United States

    Site Not Available

  • Consano Clinical Research, LLC

    Shavano Park 4728147, Texas 4736286 78231
    United States

    Site Not Available

  • Chrysalis Clinical Research

    Saint George, Utah 84790
    United States

    Site Not Available

  • Southwest Internal Medicine, PC

    Saint George, Utah 84790
    United States

    Site Not Available

  • Chrysalis Clinical Research

    St. George 5546220, Utah 5549030 84790
    United States

    Site Not Available

  • Southwest Internal Medicine, PC

    St. George 5546220, Utah 5549030 84790
    United States

    Site Not Available

  • Selma Medical Associates

    Winchester, Virginia 22601
    United States

    Site Not Available

  • Selma Medical Associates

    Winchester 4794120, Virginia 6254928 22601
    United States

    Site Not Available

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