EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations

Inclusion Criteria (Aims 1, 2, and 3) for Group 1 (50 through 80 years of age):

• Non-tobacco using (currently)

• Self-identify as East Asian (including Southeast Asian) or Hispanic/Latinx.

• East Asian includes those who self-identify as Chinese, Japanese, Korean, Taiwanese, Malaysian

• Southeast Asian includes those who self-identify as Cambodian, Thai, Vietnamese, Filipino

• Latinx includes those who self-identify as a person of Central or South American and the Caribbean including, Cuban, Puerto Rican, and Dominican culture or origin, excluding individuals originating from Spain

• Aims 1 and 2: Able to complete and understand the study's informed consent in English, Mandarin, Cantonese, Japanese, Korean, Vietnamese, Spanish, Portuguese, or Cape Verdean

• Aim 3: Able to complete and understand the study's informed consent and participate in a focus group in English, Mandarin, Vietnamese, or Spanish.

Inclusion Criteria (Aims 1, 2, and 3) for Group 2 (40 through 49 years of age):

• Non-tobacco using (currently)

• Self-identify as East Asian (including Southeast Asian) or Latinx, if any of the following criteria are met:

• Family history of EGFR positive LC L858R or exon 19

• Personal history of remote cancer that is not LC or other thoracic malignancies, including thymoma, thymic carcinoma, or sarcoma, as long as it was resolved over 5 years ago

• History of TB, asthma requiring daily inhaled corticosteroids or chronic bronchitis

• Symptoms of lung cancer for the past month, including hemoptysis, unexplained weight loss, voice hoarseness, cough or worsening cough, dyspnea or worsening dyspnea

• Excluding individuals who concurrently present with fever, covid/influenza/RSV/adenovirus infection, runny nose, sore throat, productive cough with green or yellow sputum

• Aims 1 and 2: Able to complete and understand the study's informed consent in English, Mandarin, Cantonese, Japanese, Korean, Vietnamese, Spanish, Portuguese, or Cape Verdean

• Aim 3: Able to complete and understand the study's informed consent and participate in a focus group in English, Mandarin, Vietnamese, or Spanish.

Exclusion Criteria (Aims 1, 2, and 3) for Groups 1 and 2:

• Having had a chest CT scan in the last 3 years or having an anticipated chest CT scan during the enrollment period.

• Having a current cancer or history of cancer within the last 5 years, excluding localized non-melanoma skin cancer and breast ductal carcinoma in situ.

• More than 400 lifetime cigarettes (i.e., 20 packs) of smoking or tobacco use

• Adults unable to provide informed consent

• Individuals <40 years of age

• Prisoners

• Pregnant women

• Personal diagnosis of lung cancer

• Not able to be compliant with study requirements