PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin

Inclusion Criteria:

• age ≥ 18 years;

• diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria)

• need for support with CRRT according to the indications of the nephrologistconsultants and Clinical Practice

• Obtaining informed consent

Exclusion Criteria:

• CRRT already ongoing (in another department not participating in the study) at thetime of transfer/admission to intensive care;

• need for RRT (any type and modality) in the 14 days prior to enrolment;

• diagnosis of AKD/CKD/ESRF on admission;

• Discontinuation of CRRT under conditions that do not comply with the criteriaestablished by the study;

• Need for CRRT not associated with AKI condition (e.g. elimination of toxicants);

• pregnant women;

• presence of known thyreopathy

• Continuous use of corticosteroids

• patient with known neoplastic disease.