A Dose-Range Study of GSBR-1290 in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

Last updated: March 7, 2025
Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Overall Status: Active - Not Recruiting

Phase

2

Condition

Diabetes Prevention

Obesity

Hypertriglyceridemia

Treatment

GSBR-1290 or Placebo

Clinical Study ID

NCT06703021
GSBR-1290-09
  • Ages 18-79
  • All Genders

Study Summary

Phase 2 clinical study will evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of various GSBR-1290 dose regimens compared with placebo in participants living with obesity or overweight with ≥ 1 weight-related comorbidity, in addition to diet and exercise, over a 36-week period.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Signed informed consent

  • BMI ≥30 kg/m2 or BMI ≥27.0 kg/m2 and previous/current diagnosis of ≥ 1 obesityrelated comorbidity

Exclusion

Exclusion Criteria:

  • Previous documented diagnosis of diabetes mellitus

  • Self-reported change in body weight >5% within 3 months before Screening

  • Have a prior or planned surgical treatment for obesity (excluding liposuction orabdominoplasty, if performed >1 year prior to screening)

  • Use of medications intended to promote weight loss, within 6 months prior toScreening

Study Design

Total Participants: 82
Treatment Group(s): 1
Primary Treatment: GSBR-1290 or Placebo
Phase: 2
Study Start date:
December 20, 2024
Estimated Completion Date:
November 30, 2025

Connect with a study center

  • ACCESS II Research Site

    Glendale, California 91206
    United States

    Site Not Available

  • ACESS II Research Site

    Montclair, California 91763
    United States

    Site Not Available

  • ACESS II Research Site

    Valparaiso, Indiana 46383
    United States

    Site Not Available

  • ACCESS II Research Site

    West Des Moines, Iowa 50265
    United States

    Site Not Available

  • ACESS II Research Site

    New York, New York 10016
    United States

    Site Not Available

  • ACESS II Research Site

    Medford, Oregon 97504
    United States

    Site Not Available

  • ACCESS II Research Site

    East Greenwich, Rhode Island 02818
    United States

    Site Not Available

  • ACCESS II Research Site

    North Charleston, South Carolina 29405
    United States

    Site Not Available

  • ACCESS II Research Site

    Dallas, Texas 75042
    United States

    Site Not Available

  • ACCESS II Research Site

    San Antonio, Texas 78240
    United States

    Site Not Available

  • ACESS II Research Site

    West Jordan, Utah 84088
    United States

    Site Not Available

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