ReadMap: Reading in Stroke Alexia and Typical Aging

Last updated: November 18, 2024
Sponsor: Georgetown University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Communication Disorders

Stroke

Cerebral Ischemia

Treatment

N/A

Clinical Study ID

NCT06700005
ReadMap
R01DC020446
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.

Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.

Eligibility Criteria

Inclusion

Inclusion criteria:

Stroke Survivors:

  • Age >= 18

  • Learned English at 8 years or younger

  • Brain injury resulting from stroke

Controls:

  • Age >= 18

  • Learned English at 8 years or younger

Exclusion criteria for all groups:

  • History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness)

  • Severe psychiatric condition that would interfere with participation in the study

  • History of diagnosed learning disorder

  • Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses/hearing aids.

  • Inability to follow study procedures despite maximal support

Additional exclusion criteria for MRIs:

  • Presence of metal in the body that is incompatible with MRI

  • Pregnancy

  • Claustrophobia

Study Design

Total Participants: 300
Study Start date:
January 12, 2023
Estimated Completion Date:
August 31, 2028

Connect with a study center

  • Georgetown University Medical Center

    Washington, District of Columbia 20057
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.