A U.S. Registry of Eosinophilic Esophagitis Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care

Last updated: September 8, 2025
Sponsor: Regeneron Pharmaceuticals
Overall Status: Active - Recruiting

Phase

N/A

Condition

Esophageal Disorders

Heartburn (Pediatric)

Heartburn

Treatment

dupilumab

Clinical Study ID

NCT06693531
R668-EE-2328
  • Ages > 12
  • All Genders

Study Summary

This observational research study is to better understand patients with eosinophilic esophagitis (EoE) who have recently been prescribed DUPIXENT® (dupilumab). The purpose of this research study is to look at how DUPIXENT is used in normal care of patients with EoE.

Possible benefits to others include a better understanding of EoE and helping to inform research and clinical trial design leading to treatment decisions in this patient population going forward.

Patient questionnaires will measure the following:

  • How EoE makes one feel

  • EoE symptoms

  • How EoE affects quality-of-life

  • How EoE impacts aspects of daily life

  • How difficult it is to swallow

  • How EoE symptoms have changed throughout the study

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Initiating treatment with DUPIXENT® for EoE according to the USPI

  2. Able to understand and complete registry-related questionnaires (includingadolescents)

Exclusion

Key Exclusion Criteria:

  1. Patients who have a contraindication to DUPIXENT® according to the USPI

  2. Treatment with DUPIXENT® within the 6 months prior to the screening assessment

  3. Participation in an ongoing interventional study on or within 6 months of thebaseline assessment. Once enrolled in registry, participation is allowed in otherongoing studies (at the discretion of the registry investigator)

NOTE: Other protocol defined inclusion/exclusion criteria apply

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: dupilumab
Phase:
Study Start date:
November 22, 2024
Estimated Completion Date:
May 09, 2030

Connect with a study center

  • Phoenix Childrens Hospital

    Phoenix, Arizona 85016
    United States

    Site Not Available

  • Arizona Digestive Health/GI Alliance

    Sun City, Arizona 85351
    United States

    Site Not Available

  • Phoenix Childrens Hospital

    Phoenix 5308655, Arizona 5551752 85016
    United States

    Active - Recruiting

  • Arizona Digestive Health/GI Alliance

    Sun City 5316201, Arizona 5551752 85351
    United States

    Active - Recruiting

  • Arkansas Childrens Hospital

    Little Rock, Arkansas 72202
    United States

    Site Not Available

  • Arkansas Childrens Hospital

    Little Rock 4119403, Arkansas 4099753 72202
    United States

    Active - Recruiting

  • University of Southern California Keck School of Medicine

    Los Angeles, California 90033
    United States

    Site Not Available

  • University of Southern California Keck School of Medicine

    Los Angeles 5368361, California 5332921 90033
    United States

    Active - Recruiting

  • Childrens Hospital Colorado

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Rocky Mountain Gastroenterology

    Littleton, Colorado 80120
    United States

    Site Not Available

  • Childrens Hospital Colorado

    Aurora 5412347, Colorado 5417618 80045
    United States

    Active - Recruiting

  • Rocky Mountain Gastroenterology

    Littleton 5429032, Colorado 5417618 80120
    United States

    Active - Recruiting

  • UConn Health

    Farmington, Connecticut 06030-8074
    United States

    Site Not Available

  • Yale School of Medicine

    New Haven, Connecticut 06510
    United States

    Site Not Available

  • UConn Health

    Farmington 4834272, Connecticut 4831725 06030-8074
    United States

    Active - Recruiting

  • Yale School of Medicine

    New Haven 4839366, Connecticut 4831725 06510
    United States

    Active - Recruiting

  • Gastroenterology of Greater Orlando

    Orange City, Florida 32763
    United States

    Site Not Available

  • Orlando Health

    Orlando, Florida 32806
    United States

    Site Not Available

  • Gastroenterology of Greater Orlando

    Orange City 4167055, Florida 4155751 32763
    United States

    Active - Recruiting

  • Orlando Health

    Orlando 4167147, Florida 4155751 32806
    United States

    Active - Recruiting

  • Emory Healthcare, Emory Clinic

    Atlanta, Georgia 30322
    United States

    Site Not Available

  • GI Care for Kids LLC

    Atlanta, Georgia 30342
    United States

    Active - Recruiting

  • Emory Healthcare, Emory Clinic

    Atlanta 4180439, Georgia 4197000 30322
    United States

    Active - Recruiting

  • GI Care for Kids LLC

    Atlanta 4180439, Georgia 4197000 30342
    United States

    Active - Recruiting

  • Comprehensive Gastrointestinal Health, LLC

    Libertyville, Illinois 60048
    United States

    Site Not Available

  • Comprehensive Gastrointestinal Health, LLC

    Libertyville 4899739, Illinois 4896861 60048
    United States

    Active - Recruiting

  • Kansas Gastroenterology LLC

    Wichita, Kansas 67226
    United States

    Site Not Available

  • Kansas Gastroenterology LLC

    Wichita 4281730, Kansas 4273857 67226
    United States

    Active - Recruiting

  • Allergy & Asthma Specialists, P.S.C.

    Owensboro, Kentucky 42301
    United States

    Site Not Available

  • Allergy & Asthma Specialists, P.S.C.

    Owensboro 4303436, Kentucky 6254925 42301
    United States

    Active - Recruiting

  • Boston Childrens Hospital

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • Boston Specialists

    Boston, Massachusetts 02111
    United States

    Active - Recruiting

  • Boston Childrens Hospital

    Boston 4930956, Massachusetts 6254926 02115
    United States

    Active - Recruiting

  • Boston Specialists

    Boston 4930956, Massachusetts 6254926 02111
    United States

    Active - Recruiting

  • Mayo Clinic

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Mayo Clinic

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Active - Recruiting

  • GI Associates and Endoscopy Center

    Flowood, Mississippi 39232
    United States

    Site Not Available

  • GI Associates and Endoscopy Center

    Flowood 4426822, Mississippi 4436296 39232
    United States

    Active - Recruiting

  • Washington University in Saint Louis

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Washington University in Saint Louis

    St Louis 4407066, Missouri 4398678 63110
    United States

    Active - Recruiting

  • Allergy Partners of N.J., P.C.

    Ocean City, New Jersey 07712
    United States

    Site Not Available

  • Allergy Partners of N.J., P.C.

    Ocean City 4503351, New Jersey 5101760 07712
    United States

    Active - Recruiting

  • Icahn School of Medicine at Mount Sinai

    New York, New York 10029
    United States

    Active - Recruiting

  • Weil Cornell Medicine NYP

    New York, New York 10065
    United States

    Site Not Available

  • Gastroenterology Group of Rochester LLP

    Rochester, New York 14618
    United States

    Active - Recruiting

  • Icahn School of Medicine at Mount Sinai

    New York 5128581, New York 5128638 10029
    United States

    Active - Recruiting

  • Weil Cornell Medicine NYP

    New York 5128581, New York 5128638 10065
    United States

    Active - Recruiting

  • Gastroenterology Group of Rochester LLP

    Rochester 5134086, New York 5128638 14618
    United States

    Active - Recruiting

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina 275997080
    United States

    Site Not Available

  • Duke University

    Durham, North Carolina 27710
    United States

    Site Not Available

  • University of North Carolina at Chapel Hill

    Chapel Hill 4460162, North Carolina 4482348 275997080
    United States

    Active - Recruiting

  • Duke University

    Durham 4464368, North Carolina 4482348 27710
    United States

    Active - Recruiting

  • Great Lakes Gastroenterology Research, LLC

    Mentor, Ohio 44060
    United States

    Site Not Available

  • Great Lakes Gastroenterology Research, LLC

    Mentor 5162645, Ohio 5165418 44060
    United States

    Active - Recruiting

  • Susquehanna Research Group

    Camp Hill, Pennsylvania 17011
    United States

    Site Not Available

  • Childrens Hospital of Philadelphia

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

  • Susquehanna Research Group

    Camp Hill 5182928, Pennsylvania 6254927 17011
    United States

    Active - Recruiting

  • Childrens Hospital of Philadelphia

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Active - Recruiting

  • University of Pennsylvania

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Active - Recruiting

  • Palmetto Gastroenterology Clinical Research

    Summerville, South Carolina 29486
    United States

    Site Not Available

  • Medical University of South Carolina

    Charleston 4574324, South Carolina 4597040 29425
    United States

    Active - Recruiting

  • Palmetto Gastroenterology Clinical Research

    Summerville 4597919, South Carolina 4597040 29486
    United States

    Active - Recruiting

  • Brooke Army Medical Center

    Fort Sam Houston, Texas 78234
    United States

    Site Not Available

  • GI Alliance

    Southlake, Texas 76092
    United States

    Site Not Available

  • Brooke Army Medical Center

    Fort Sam Houston 7267736, Texas 4736286 78234
    United States

    Active - Recruiting

  • Baylor College of Medicine

    Houston 4699066, Texas 4736286 77030
    United States

    Active - Recruiting

  • GI Alliance

    Southlake 4733313, Texas 4736286 76092
    United States

    Active - Recruiting

  • Tanner Clinic

    Layton, Utah 84041
    United States

    Site Not Available

  • Tanner Clinic

    Layton 5777107, Utah 5549030 84041
    United States

    Active - Recruiting

  • University of Virginia

    Charlottesville, Virginia 22908
    United States

    Site Not Available

  • University of Virginia

    Charlottesville 4752031, Virginia 6254928 22908
    United States

    Active - Recruiting

  • Washington Gastroenterology, GIA

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Seattle Children's Home Health Company

    Seattle 5809844, Washington 5815135 98105
    United States

    Active - Recruiting

  • Washington Gastroenterology, GIA

    Tacoma 5812944, Washington 5815135 98405
    United States

    Active - Recruiting

  • Medical College of Wisconsin

    Milwaukee, Wisconsin 53226
    United States

    Site Not Available

  • Medical College of Wisconsin

    Milwaukee 5263045, Wisconsin 5279468 53226
    United States

    Active - Recruiting

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