A U.S. Registry of Eosinophilic Esophagitis Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care

Last updated: May 7, 2025
Sponsor: Regeneron Pharmaceuticals
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heartburn (Pediatric)

Heartburn

Esophageal Disorders

Treatment

dupilumab

Clinical Study ID

NCT06693531
R668-EE-2328
  • Ages > 12
  • All Genders

Study Summary

This observational research study is to better understand patients with eosinophilic esophagitis (EoE) who have recently been prescribed DUPIXENT® (dupilumab). The purpose of this research study is to look at how DUPIXENT is used in normal care of patients with EoE.

Possible benefits to others include a better understanding of EoE and helping to inform research and clinical trial design leading to treatment decisions in this patient population going forward.

Patient questionnaires will measure the following:

  • How EoE makes one feel

  • EoE symptoms

  • How EoE affects quality-of-life

  • How EoE impacts aspects of daily life

  • How difficult it is to swallow

  • How EoE symptoms have changed throughout the study

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Initiating treatment with DUPIXENT® for EoE according to the USPI

  2. Able to understand and complete registry-related questionnaires (includingadolescents)

Exclusion

Key Exclusion Criteria:

  1. Patients who have a contraindication to DUPIXENT® according to the USPI

  2. Treatment with DUPIXENT® within the 6 months prior to the screening assessment

  3. Participation in an ongoing interventional study on or within 6 months of thebaseline assessment. Once enrolled in registry, participation is allowed in otherongoing studies (at the discretion of the registry investigator)

NOTE: Other protocol defined inclusion/exclusion criteria apply

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: dupilumab
Phase:
Study Start date:
November 22, 2024
Estimated Completion Date:
May 09, 2030

Connect with a study center

  • Phoenix Childrens Hospital

    Phoenix, Arizona 85016
    United States

    Active - Recruiting

  • Arizona Digestive Health/GI Alliance

    Sun City, Arizona 85351
    United States

    Active - Recruiting

  • Rocky Mountain Gastroenterology

    Littleton, Colorado 80120
    United States

    Active - Recruiting

  • UConn Health

    Farmington, Connecticut 06030-8074
    United States

    Active - Recruiting

  • Gastroenterology of Greater Orlando

    Orange City, Florida 32763
    United States

    Active - Recruiting

  • Emory Healthcare, Emory Clinic

    Atlanta, Georgia 30322
    United States

    Active - Recruiting

  • GI Care for Kids LLC

    Atlanta, Georgia 30342
    United States

    Active - Recruiting

  • Comprehensive Gastrointestinal Health, LLC

    Libertyville, Illinois 60048
    United States

    Active - Recruiting

  • Kansas Gastroenterology LLC

    Wichita, Kansas 67226
    United States

    Active - Recruiting

  • Boston Specialists

    Boston, Massachusetts 02111
    United States

    Active - Recruiting

  • GI Associates and Endoscopy Center

    Flowood, Mississippi 39232
    United States

    Active - Recruiting

  • Allergy Partners of N.J., P.C.

    Ocean City, New Jersey 07712
    United States

    Active - Recruiting

  • Icahn School of Medicine at Mount Sinai

    New York, New York 10029
    United States

    Active - Recruiting

  • Gastroenterology Group of Rochester LLP

    Rochester, New York 14618
    United States

    Active - Recruiting

  • Great Lakes Gastroenterology Research, LLC

    Mentor, Ohio 44060
    United States

    Active - Recruiting

  • Susquehanna Research Group

    Camp Hill, Pennsylvania 17011
    United States

    Active - Recruiting

  • Palmetto Gastroenterology Clinical Research

    Summerville, South Carolina 29486
    United States

    Active - Recruiting

  • GI Alliance

    Southlake, Texas 76092
    United States

    Active - Recruiting

  • Tanner Clinic

    Layton, Utah 84041
    United States

    Active - Recruiting

  • Washington Gastroenterology, GIA

    Tacoma, Washington 98405
    United States

    Active - Recruiting

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