Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD

Last updated: August 11, 2025
Sponsor: Zhen Wang
Overall Status: Active - Recruiting

Phase

N/A

Condition

Panic Disorders

Anxiety Disorders

Obsessive-compulsive Disorder

Treatment

Deep Transcranial Magnetic Stimulation, DTMS sham

Deep Transcranial Magnetic Stimulation, DTMS active

Clinical Study ID

NCT06692114
SMHC-OCD-012
  • Ages 18-50
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study aims to explore the efficacy and influencing of accelerated dTMS (deep Transcranial Magnetic Stimulation) treatment in patients with obsessive-compulsive disorder (OCD), and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged between 18 and 50, both genders are welcome.

  • DSM-5 criteria for OCD.

  • Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of atleast one full course of CBT. The treatment regimen must have been stable for atleast 8 weeks prior to enrollment and remain unchanged throughout the study.

  • More than 9 years of education.

  • Right-handed.

Exclusion

Exclusion Criteria:

  • Any additional current psychiatric comorbidity, except for obsessive- compulsivepersonality disorder.

  • Severe obsessive symptoms prevent the completion of necessary assessments.

  • Has a history of receiving ECT therapy.

  • Has received rTMS or tDCS treatment within the past two months.

  • Has severe physical illnesses or any physical conditions that can induce epilepsy orintracranial hypertension, including cardiovascular and respiratory diseases, amongothers.

  • Has a past history of neurological disorders (such as epilepsy, cerebrovascularaccidents, etc.) or brain injuries, or a history of brain surgery.

  • Has implanted medical devices such as intracranial stents, cardiac pacemakers,coronary stents, cochlear implants, etc.

  • Serious suicide risk.

  • Pregnancy or nursing of an infant.

Study Design

Total Participants: 70
Treatment Group(s): 2
Primary Treatment: Deep Transcranial Magnetic Stimulation, DTMS sham
Phase:
Study Start date:
July 26, 2024
Estimated Completion Date:
September 01, 2027

Study Description

The study is to recruit eligible patients with obsessive-compulsive disorder (OCD) from the Shanghai Mental Health Center for deep transcranial magnetic stimulation (dTMS) intervention, and recruit healthy controls who meet the enrollment criteria from the community. Among them, patients with OCD will be randomly divided into a real stimulation group and a sham stimulation group. After baseline assessment, dTMS treatment will be administered twice a day. EEG data collection, MRI data, cognitive tasks, psychological self-assessment scales and clinical symptom assessment will be conducted before treatment and 2 weeks after treatment. During the treatment process, patients will receive two treatments per day, each lasting 20 minutes, for a total of 2 weeks, or 28 treatments in total.

Connect with a study center

  • Shanghai Mental Health Center

    Shanghai, Shanghai 200030
    China

    Active - Recruiting

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