Integrative Training Program for Pediatric Sickle Cell Pain

Inclusion Criteria:

• Provision of signed and dated informed consent form for adolescents 18 years old andcaregivers' participation

• For children <18, informed assent and parental informed consent to participate inthe study

• Willingness to comply with all study procedures and lifestyle considerations andavailability for the duration of the study

• Males and females; Ages 12-18 years for adolescents; no age limitations forcaregivers

• Documented diagnosis of sickle cell disease (any genotype) for adolescents

• Adolescent scores at least 3 on the Pediatric Pain Screening Tool

• Adolescent reports typical pain intensity in the past week at least 4 on a 0-10 cmVisual Analog Scale

• Adolescent on stable disease-modifying treatments, if applicable (e.g., hydroxyurea,glutamine, voxelotor, crizanlizumab) as defined by not newly initiated orsignificantly increased dosages (mg/kg) in the past 3 months

• Speak and read English

Exclusion Criteria:

• An adolescent has comorbid medical conditions typically associated with pain butunrelated to SCD (e.g., rheumatologic disorders or inflammatory bowel disease)

• Adolescent has undergone genetic or hematopoietic stem cell therapy

• Presence of a condition(s) or diagnosis, either physical or psychological, orphysical exam finding that precludes participation

• Adolescents receiving active treatment (e.g., weekly appointments with a provider)for nonpharmacological therapies (e.g., structured behavioral pain management,physical therapy, or acupuncture program) that overlap with the active phase of thestudy intervention