CLINICAL INVESTIGATION FOR THE EVALUATION OF EFFICACY AND SAFETY OF TWO PRODUCTS FOR THE TREATMENT OF ONYCHOMYCOSIS

Inclusion Criteria:

• 1. Patient having given freely her/his informed, written consent. 2. Patient havinga good general health. 3. Age: between 18 and 70 years; 4. Patient with superficialonychomycosis on at least one great toenail or fingernail (for at least 10% in eacharm) or light to moderate disto-lateral onychomycosis (without matrix involvementand involvement <2/3 of the tablets).

5. Patient with positive KOH staining. 6. Patient cooperative and aware of theproducts modalities of use and the necessity and duration of the controls so thatperfect adhesion to the protocol can be expected.

6. Patient being psychologically able to understand information and to givetheir/his/her consent.

7. Patient having stopped any systemic antifungal treatment since at least 6 monthsbefore screening and/or any topical antifungal treatment since at least 3 monthsbefore screening.

8. Patient who agree to refrain from receiving pedicure/manicure, artificial nailsand/or cosmetic nail varnish or other medication on the nail being treated for theentire study duration.

9. Female of childbearing potential should use a contraceptive regimen recognizedas effective since at least 12 weeks before screening visit, during all the studyand at least 1 month after study end.

Exclusion Criteria:

• 1. Pregnant, breastfeeding woman or woman planning a pregnancy during the study; 2. Patient considered by the investigator likely to be non-compliant with the protocol. 3. Patient enrolled in another clinical trial or which exclusion period is not over. 4. Patient with a condition or receiving a medication which, in the investigator's judgment, put the patient at undue risk; 5. Patient suffering from a severe or progressive disease (to investigator's discretion) such as uncontrolled diabetes, peripheral circulatory disease, HIV, psoriasis, lichen planus, immunosuppressive pathology… 6. Patient having a known allergy or hypersensitivity to one of the constituents of the tested products.

7. Patient with cutaneous pathology on studied zone (other than onychomycosis like angioma, dermatitis…).