68Ga-JH12 PET/CT: Dosimetry and Biodistribution Study

Last updated: November 12, 2024
Sponsor: First Affiliated Hospital of Fujian Medical University
Overall Status: Active - Recruiting

Phase

1

Condition

Neoplasms

Treatment

68Ga-JH12

Clinical Study ID

NCT06688188
FirstAHFujian-68Ga-JH12
  • Ages 18-80
  • All Genders

Study Summary

68Ga-JH12 is a novel radiotracer targeting C-X-C motif chemokine receptor 4 (CXCR4). In this study, we observed the safety, biodistribution, and radiation dosimetry of 68Ga-JH12 in patients with different types of cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Various solid tumors with available histopathological findings

  • Signed informed consent

Exclusion

Exclusion Criteria:

  • pregnant or lactational women

  • who suffered from severe hepatic and renal insufficiency

Study Design

Total Participants: 5
Treatment Group(s): 1
Primary Treatment: 68Ga-JH12
Phase: 1
Study Start date:
November 01, 2024
Estimated Completion Date:
December 31, 2025

Study Description

C-X-C motif chemokine receptor 4 (CXCR4) is highly expressed in patients affected with malignant tumors and ex-vivo analyses provided evidence that the expression level on the tumor cell surface is tightly linked to the proliferation index. In recent years, the diagnostic PET agent 68Ga-Pentixafor targeting this chemokine receptor has been extensively validated in haematological malignancies and solid tumors. 68Ga-JH12, a novel radiopharmaceutical targeting CXCR4, demostrated high stability in vitro and in vivo, and can accumulate specifically in tumors with high binding affinity, safety, and selectivity in preclinical studies. In this study, the safety, biodistribution, and radiation dosimetry of 68Ga-JH12 in patients with Various Cancers were observed to evaluate the dosimetric characteristics of 68Ga-JH12.

Connect with a study center

  • Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University

    Fuzhou, Fujian 350005
    China

    Active - Recruiting

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