Effectiveness of Digital Cognitive Behavioral Therapy for the Treatment of Depression

Inclusion Criteria:

1. Aged 18-45 years (including 18 and 45), no gender restriction;

2. Meets the diagnostic criteria for depressive disorders according to the Diagnosticand Statistical Manual of Mental Disorders, Fifth Edition (DSM-IV);

3. Outpatients or inpatients; Hamilton Depression Rating Scale 17-item (HAMD-17) score ≥ 17; Clinical Global Impressions-Severity (CGI-S) score = 4;

4. Maintenance treatment with antidepressants in the class of Selective SerotoninReuptake Inhibitors (SSRIs) for at least 4 weeks, or no previous treatment withantidepressants, and can be combined with Lorazepam 0.5mg/dose and Zolpidem Tartrate 5-10mg/n during insomnia and anxiety attacks;

5. Written informed consent obtained from the patient.

Exclusion Criteria:

1. Diagnosed with other mental disorders, including schizophrenia, bipolar disorder,alcohol or substance abuse/dependence, eating disorders, etc.;

2. Individuals with intellectual disabilities or who are unable to cooperate for otherreasons, or those lacking or having incomplete civil capacity during the onset ofillness;

3. Suffering from neurological or organic brain diseases (such as stroke, cerebralhemorrhage, brain tumors, Parkinson's disease, epilepsy, etc.) and a history ofsevere traumatic brain injury;

4. Currently undergoing systematic psychological therapy;

5. Individuals who had been treated with convulsion-free electroconvulsive therapywithin the last month;

6. Pregnant women or individuals with contraindications to MRI examinations;

7. Individuals who don't know how to use or don't have a smartphone;

8. Individuals with severe suicidal tendencies or at risk of harming others.