Electrical Stimulation for Vision Neuroenhancement in Glaucoma

Inclusion Criteria:

• Participant must be at least 18.

• Participant must has the ability to comply with the requirements of the study andcomplete the schedule of events (SOE).

• Participant's clinical diagnosis must be consistent with primary open angle glaucoma (including but not limited to normal tension, low tension or general open angle)characterized by the following features: Mean deviation (MD) worse than -6 butbetter than -20 on reliable Humphrey Visual Field 24-2 testing

• Participant's eye pressure must be clinically stable, with IOP < 18.

• If a participant has two eyes meeting study criteria, the worse eye as determined byvisual field index (VFI) or patient preference, will be deemed includable. If botheyes qualify and have the same VFI, the patient may choose which eye they arewilling to enter, or else a randomization procedure will assign one eye to thestudy.

• Participant must understand and sign the informed consent. If the participant'svision is impaired to the point where he/she cannot read the informed consentdocument, the document will be read to the participant in its entirety.

Exclusion Criteria:

• Participant is unable to comply with study procedures or follow-up visits.

• Participant has a history of ocular herpes zoster.

• Participant has a requirement of acyclovir and/or related products during studyduration. To be eligible for this study, the participant must discontinue use ofthese products prior to enrollment and must not continue with the products untilafter they have completed the study.

• Participant has evidence of corneal opacification or lack of optical clarity.

• Participant has uveitis or other ocular inflammatory disease.

• Participant is receiving systemic steroids or other immunosuppressive medications.

• Participant is currently participating in or has within the last 3 monthsparticipated in any other clinical trial of a drug by ocular (if in the study eye)or systemic administration.

• Participant is pregnant or lactating.

• Participant has, in the opinion of the investigator, any physical or mentalcondition that would increase the risk of participation in the study or mayinterfere with the study procedures, evaluations and outcome assessments.

• Patients with opened skull, after trepanation or with heart and brain pacemaker.

• Patients with implanted intracranial metals such as clippings, coilings,ventriculo-peritoneal shunts, endoprosthesis etc.

• Patients with any skin damage in the area of electrode placement.

• Children and comatose patients.

• Patients with recent history of epileptic seizure.

• Patients with uncontrolled high levels of blood pressure (<160 mmHg) or uncontrolledhigh levels of intraocular pressure (<27 mmHg).

• Patients abusing drugs or alcohol.