Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)

Last updated: February 5, 2025
Sponsor: Children's Hospital Los Angeles
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Injury

Acute Respiratory Distress Syndrome (Ards)

Respiratory Failure

Treatment

Electrical Impedance Tomography positive end-expiratory pressure titration

Clinical Study ID

NCT06684119
CHLA-24-00295
  • Ages < 18
  • All Genders

Study Summary

The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced. The primary and secondary aims of the study are as follows:

Identify the difference between the optimal PEEP recommended by EIT metrics and the current guideline recommended approach to identifying optimal PEEP in PARDS. There will be a statistically significant difference in the recommended optimal PEEP identified using the EIT PEEP titration tool and that of the PEEP/FiO2 grid recommendations.

Determine the difference in physiologic metrics between EIT optimal PEEP and the PEEP/FiO2 recommended PEEP.

Participants will undergoing EIT monitoring while being subjected to PEEP titration protocol.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Any person who is less than 18 years of age

  • is on invasive mechanical ventilation

  • is not spontaneously breathing

  • meets PARDS criteria

Exclusion

Exclusion Criteria:

  • Contraindication to the use of EIT

  • Hemodynamic instability

  • Contraindications to hypercapnia

  • patients with uncuffed endotracheal or tracheostomy tubes

  • diagnosis of pneumothorax or bronchopleural fistula

  • non-conventional ventilation

  • any patient on extra-corporeal membrane oxygenation (ECMO) support

  • less than 1 week post-operatively from cardiac surgery

  • the following cardiac diagnoses: Glenn or Fontan physiology, significant right toleft shunt

  • Corrected Gestational Age < 37 weeks

  • pregnancy

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: Electrical Impedance Tomography positive end-expiratory pressure titration
Phase:
Study Start date:
December 10, 2024
Estimated Completion Date:
July 01, 2027

Connect with a study center

  • Children's Hospital Los Angeles

    Los Angeles, California 90027
    United States

    Active - Recruiting

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