A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight

Inclusion Criteria:

W8M-MC-GN01:

• Assigned male at birth

• Assigned female at birth, who are of non-childbearing potential

W8M-MC-CWMM:

• Have a BMI of

• ≥ 30 kilograms per square meter (kg/m²) or

• ≥ 27 kg/m² and < 30 kg/m² with at least one weight-related comorbidity

• Have had a stable body weight for the 3 months prior to randomization (<5% bodyweight gain and/or loss)

Exclusion Criteria:

W8M-MC-GN01:

• Have Type 2 Diabetes Mellitus or Type 1 Diabetes Mellitus

• Have a history of acute or chronic pancreatitis

• Have renal impairment

• Individuals who are of childbearing potential

W8M-MC-CWMM:

• Have a prior or planned surgical treatment for obesity, except prior liposuction orabdominoplasty, if performed >1 year prior to screening.

• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history ofketoacidosis or hyperosmolar coma.

• Have poorly controlled hypertension.

• Have signs and symptoms of any liver disease other than nonalcoholic fatty liverdisease.

• Have any of the following cardiovascular conditions within 3 months prior toscreening:

• acute myocardial infarction

• cerebrovascular accident (stroke)

• unstable angina, or

• hospitalization due to congestive heart failure.

• Have a history of symptomatic gallbladder disease within the past 2 years

• Have a lifetime history of suicide attempts.