Developing a Novel Therapy for Aversive Sensory Experiences in Autism

Last updated: January 20, 2025
Sponsor: King's College London
Overall Status: Active - Recruiting

Phase

N/A

Condition

Autism

Autism Spectrum Disorder (Asd)

Treatment

Group Cognitive Behavioural Therapy

Clinical Study ID

NCT06682858
346716
  • Ages 11-16
  • All Genders

Study Summary

The goal of this study is to assess whether a new psychological treatment can lead to changes in sensory experiences in autistic young people. Participants will complete a group intervention designed to help manage sensory difficulties and associated anxiety. Participants will also complete tasks before and after the intervention to assess whether the treatment can lead to changes in brain and behavioural responses to sensory experiences.

The main questions the study aims to answer are:

  1. Does the intervention improve sensory difficulties and associated anxiety in autistic young people?

  2. Does the intervention change brain and biological responses to sensory experiences in autistic young people?

Researchers will also collect feedback from participants to help improve the design and delivery of the treatment in future studies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Confirmed clinical diagnosis of autism

  • Verbal/intellectual ability in average range

  • Sufficient spoken English to be able to access the intervention

  • Under the care of a local mental health service

  • Not currently taking part in another psychological intervention

Exclusion

Exclusion Criteria:

  • Verbal/intellectual ability below the average range

  • Insufficient spoken English to be able to access the intervention

  • Currently receiving a psychological intervention

  • Individuals at high risk of harm to themselves or others

Study Design

Total Participants: 34
Treatment Group(s): 1
Primary Treatment: Group Cognitive Behavioural Therapy
Phase:
Study Start date:
November 29, 2024
Estimated Completion Date:
September 30, 2025

Study Description

The purpose of this study is to pilot a group-based cognitive behavioural therapy (CBT) intervention focused on managing sensory differences associated with autism. Another aim of this study is to test whether the intervention can modulate perceptual and neurophysiological markers (e.g. via electrocephalogram [EEG], heart rate and skin conductance) of sensory processing in autistic children and adolescents. A final aim will be to collect qualitative feedback from autistic young people with the aim of refining and improving the intervention for larger studies in the future.

The main aims of the study are:

  1. To assess the feasibility of a novel CBT intervention for the management of sensory difficulties and associated anxiety in autistic youth.

  2. To gather proof-of-concept data that the intervention can be used to modulate sensory neurophysiological and perceptual markers.

  3. To gather qualitative feedback and PPIE to inform refinements on the design and delivery of the intervention for further studies.

Connect with a study center

  • King's College London

    London,
    United Kingdom

    Active - Recruiting

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