A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria:

• Must be a candidate for standard of care (SOC) treatment of non small cell lungcancer (NSCLC) by concurrent platinum-based doublet chemotherapy with radiationtherapy (cCRT) followed by consolidation durvalumab treatment as determined by theinvestigator and per local guidelines at screening

• Have a medical history of pathologically (histologically or cytologically) provendiagnosis of NSCLC within 3 months prior to enrollment/randomization

• Have locally advanced unresectable stage III NSCLC according to the eighth editionlung cancer stage classification

• Have at least 1 target lesion (primary lung lesion or involved lymph node[s]) perRECIST version 1.1 that is amenable to intratumoral and/or intranodal injection andintensity modulated radiation therapy (IMRT) as determined by the investigator atscreening

• Have an eastern cooperative oncology group (ECOG) performance status of 0 to 1

Exclusion Criteria:

• Medical history of: (a) Primary immunodeficiency (b) Organ transplant that requirestherapeutic immunosuppression

• Any of the following within 3 months prior to enrollment/randomization: severe orunstable angina, myocardial infarction, clinically significant ventriculararrhythmias or heart failure New York heart association functional classificationclass III to IV

• Another concurrent or prior primary malignancy within the last 36 months at informedconsent

• Known allergies, hypersensitivity, or intolerance to any ingredients of JNJ-90301900crystalline solution, platinum-based doublet chemotherapy (ChT), or durvalumab

• History of coagulation disorders, including: (a) Active bleeding diathesis orrequirement for therapeutic anticoagulation or antiplatelet that cannot beinterrupted or altered for JNJ-90301900 injection procedures, (b) Majorthromboembolic events (for example, pulmonary embolism, cerebrovascular accident)within 3 months of enrollment or randomization