Evaluating Modulation Effects of Temporal Interference Using SEEG

Last updated: February 3, 2025
Sponsor: Xuanwu Hospital, Beijing
Overall Status: Active - Recruiting

Phase

N/A

Condition

Epilepsy

Treatment

Temporal Interference

Clinical Study ID

NCT06663969
2024-258-002
  • Ages 14-65
  • All Genders

Study Summary

This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with drug-resistant epilepsy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis of drug-resistant epilepsy;

  • No severe systemic diseases;

  • Implantation of stereotactic electrodes;

  • Agreement to participate in this study and signs the informed consent form.

Exclusion

Exclusion Criteria:

  • Hematoma at the scalp electrode site or fluid accumulation under the electrode afterintracranial electrode placement.

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Temporal Interference
Phase:
Study Start date:
November 04, 2024
Estimated Completion Date:
October 31, 2025

Study Description

Temporal Interference (TI) technology is a novel non-invasive method for deep brain stimulation (DBS). By generating an overlapping electric field from safe currents, TI creates focused stimulation in targeted deep brain areas. This approach allows for the exploration of deep brain nuclei functions and has the potential to serve as a non-invasive alternative to traditional invasive DBS for clinical treatments.

Stereoelectroencephalography (SEEG) is a method for recording electrical activity from deep brain structures using implanted depth electrodes to provide a three-dimensional view of neuronal activity.

This study aims to investigate the electrophysiological mechanisms of temporal interference (TI) deep brain stimulation by including patients aged 14-60 with implanted intracranial electrodes. During and after TI stimulation, electrophysiological and clinical data will be recorded. Clinical, imaging, and electrophysiological data will be analyzed and processed to advance understanding of TI's effects in deep brain stimulation.

Connect with a study center

  • Xuanwu Hospital,Capital Medical University

    Beijing, Beijing 100053
    China

    Active - Recruiting

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