Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

Last updated: June 24, 2025
Sponsor: Alliance for Clinical Trials in Oncology
Overall Status: Active - Recruiting

Phase

3

Condition

Urologic Cancer

Urothelial Tract Cancer

Urothelial Cancer

Treatment

Biospecimen Collection

Questionnaire Administration

Pembrolizumab

Clinical Study ID

NCT06661720
A032201
NCI-2024-08233
  • Ages > 18
  • All Genders

Study Summary

This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with high-risk renal cell carcinoma (RCC). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Tivozanib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells. Giving pembrolizumab and tivozanib together may work better than pembrolizumab alone in treating patients with RCC.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • • Histologically confirmed diagnosis of RCC with clear cell component with or without sarcomatoid features following complete resection of the primary tumor (radical or partial nephrectomy)

  • Note: Patients with microscopically positive soft tissue or vascular margins without gross residual disease are permitted

  • Intermediate-high risk RCC:

  • pT2 grade 4 or sarcomatoid features, N0M0

  • pT3 any grade N0, M0

  • High-risk RCC

  • pT4, any grade, N0, M0

  • pT, any stage., any grade, N+, M0

  • cM1 no evidence of disease (NED) RCC

  • Participants who have had resection of primary tumor (radical or partical nephrectomy) and resection or definitive radiation or ablation of solid, isolated, soft tissue metastases (excluding brain and bone lesions) at the time of primary tumor removal (synchronous) or ≤1 year from primary tumor removal (metachronous)

  • Surgery (radical or partial nephrectomy or metastasectomy or ablation) > 4 weeks but =< 16 weeks prior to study registration with no ongoing complications from surgery

  • No evidence of disease at time of randomization as assessed by investigator by either CT or MRI scan of the brain and chest, abdomen and pelvis

  • No prior systemic treatment for RCC

  • Age >= 18 years

  • Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (or Karnofsky >= 60%)

  • Absolute neutrophil count (ANC) >= 1,000/mm^3

  • Platelet count >= 100,000/mm^3

  • Hemoglobin >= 8 g/dL

  • Total bilirubin =< 3 x upper limit of normal (ULN)

  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x upper limit of normal (ULN)

  • Calculated (calc.) creatinine clearance >= 30 mL/min (using Cockcroft Gault equation or the estimated glomerular filtration rate from the modification of diet in renal disease trial)

  • Urine protein =< 1+ on urine analysis (UA) or urine protein creatinine ration (UPCR) < 2mg/mg

  • Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test is required =< 14 days prior to registration

  • HIV status: HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

  • Hepatitis

  • Hepatitis B: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. Patients with resolved HBV infection, defined as positive hepatitis B core antibody (anti-HBc) and negative hepatitis B surface antigen (HbsAg), are eligible

  • Hepatitis C: Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

  • Cardiac Disease: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class IIB or better

  • No history of myocarditis

  • No history of clinically significant pneumonitis

  • No uncontrolled hypertension (systolic blood pressure [BP] > 150 mm Hg or diastolic BP > 90 mm Hg) documented on 2 consecutive measurements taken at least 2 hours apart

  • No serious non-healing wound, ulcer or bone fracture within 28 days prior to registration

  • No serious/active infection requiring parenteral antibiotics

  • No moderate or severe hepatic impairment (child-Pugh B or C)

  • No significant bleeding disorders within 1 month prior to registration, for example:

  • Hematemesis, hematochezia or other gastrointestinal bleeding grade 3 or higher

  • Hemoptysis of pulmonary bleeding grade 3 or higher

  • Hematuria or other genitourinary bleeding grade 3 or higher

  • No history of allogeneic organ transplantation

  • No history of allergy of hypersensitivity to study drugs or components

  • No condition requiring systemic treatment with either corticosteroid (> 10 mg daily or prednisone equivalent) within 14 days of treatment initiation or other immunosuppressive medications within 30 days of randomization. Inhaled or topical steroids and adrenal replacement doses ≤10 mg daily prednisone equivalent are permitted in absence of active autoimmune disease

  • No active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis or other gastrointestinal condition associated with increased risk of perforation; history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 4 weeks prior to registration

  • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

  • No patients with a history of autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids > 10 mg/day, or immunosuppressive drugs) with the following exceptions:

  • Replacement therapy (e.g., thyroxine, insulin, physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed

  • Brief (<7 days) use of systemic corticosteroids is allowed when use is considered standard of care

  • Patients with vitiligo, psoriasis, type 1 diabetes mellitus, hypothyroidism, or resolved childhood asthma/atopy will not be excluded

  • Patients requiring intermittent use of bronchodilators, inhaled steroids, or local steroid injections will not be excluded

  • Patients with hypothyroidism that is stable with hormone replacement or Sjögren's syndrome will not be excluded • Chronic concomitant treatment with strong CYP3A4 inducers is not allowed. Patients must discontinue the drug 14 days prior to the start of study treatment

Study Design

Total Participants: 1040
Treatment Group(s): 7
Primary Treatment: Biospecimen Collection
Phase: 3
Study Start date:
March 14, 2025
Estimated Completion Date:
November 30, 2037

Study Description

PRIMARY OBJECTIVE:

I. To compare disease free survival (DFS) as assessed by the investigator for high-risk renal cell carcinoma patients treated with adjuvant pembrolizumab and tivozanib versus those receiving pembrolizumab alone.

SECONDARY OBJECTIVES:

I. To compare overall survival (OS) for patients treated with adjuvant pembrolizumab and tivozanib versus those receiving pembrolizumab alone.

II. To assess adverse events in each study arm by Common Terminology Criteria for Adverse Events (CTCAE) 5.0.

BIOBANKING OBJECTIVE:

I. To bank specimens for future unspecified research.

QUALITY OF LIFE (QOL) OBJECTIVES:

I. To compare global quality of life (QOL) for patients treated with pembrolizumab and tivozanib versus those receiving pembrolizumab alone.

II. To compare patient-reported fatigue for patients treated with pembrolizumab and tivozanib versus those receiving pembrolizumab alone.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive pembrolizumab intravenously (IV) on days 1 and 43 of each cycle, or on days 1, 22, 43 and 64 of each cycle. Cycles repeat every 12 weeks for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo blood sample collection and magnetic resonance imaging (MRI) or computed tomography (CT) throughout the trial and may undergo tissue biopsy on study.

ARM II: Patients receive pembrolizumab IV on days 1 and 43 of each cycle and tivozanib orally (PO) once daily (QD) on days 1-21, days 29-49, and days 57-77 of each cycle for up to 6 months. Cycles repeat every 12 weeks for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo blood sample collection and MRI or CT throughout the trial and may undergo tissue biopsy on study.

After completion of study treatment, patients are followed up every 4 months for 2 years, then every 6 months for 3 years, then every subsequent year for 5 years.

Connect with a study center

  • Cancer Center at Saint Joseph's

    Phoenix, Arizona 85004
    United States

    Active - Recruiting

  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    Jonesboro, Arkansas 72401
    United States

    Active - Recruiting

  • City of Hope Comprehensive Cancer Center

    Duarte, California 91010
    United States

    Active - Recruiting

  • City of Hope at Irvine Lennar

    Irvine, California 92618
    United States

    Active - Recruiting

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    Irvine, California 92612
    United States

    Active - Recruiting

  • City of Hope Antelope Valley

    Lancaster, California 93534
    United States

    Active - Recruiting

  • Los Angeles General Medical Center

    Los Angeles, California 90033
    United States

    Active - Recruiting

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California 90033
    United States

    Active - Recruiting

  • USC Norris Oncology/Hematology-Newport Beach

    Newport Beach, California 92663
    United States

    Active - Recruiting

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California 92868
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California 94301
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation-Santa Cruz

    Santa Cruz, California 95065
    United States

    Active - Recruiting

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California 94086
    United States

    Active - Recruiting

  • City of Hope South Bay

    Torrance, California 90503
    United States

    Active - Recruiting

  • City of Hope Upland

    Upland, California 91786
    United States

    Active - Recruiting

  • Smilow Cancer Hospital-Derby Care Center

    Derby, Connecticut 06418
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center-Fairfield

    Fairfield, Connecticut 06824
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center at Glastonbury

    Glastonbury, Connecticut 06033
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center at Greenwich

    Greenwich, Connecticut 06830
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center - Guilford

    Guilford, Connecticut 06437
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center at Saint Francis

    Hartford, Connecticut 06105
    United States

    Active - Recruiting

  • Yale University

    New Haven, Connecticut 06520
    United States

    Active - Recruiting

  • Yale-New Haven Hospital North Haven Medical Center

    North Haven, Connecticut 06473
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center at Long Ridge

    Stamford, Connecticut 06902
    United States

    Active - Recruiting

  • Stamford Hospital/Bennett Cancer Center

    Stamford, Connecticut 06904
    United States

    Active - Recruiting

  • Smilow Cancer Hospital-Torrington Care Center

    Torrington, Connecticut 06790
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center-Trumbull

    Trumbull, Connecticut 06611
    United States

    Active - Recruiting

  • Smilow Cancer Hospital-Waterbury Care Center

    Waterbury, Connecticut 06708
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center - Waterford

    Waterford, Connecticut 06385
    United States

    Active - Recruiting

  • Beebe South Coastal Health Campus

    Millville, Delaware 19967
    United States

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  • Helen F Graham Cancer Center

    Newark, Delaware 19713
    United States

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  • Medical Oncology Hematology Consultants PA

    Newark, Delaware 19713
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  • Beebe Health Campus

    Rehoboth Beach, Delaware 19971
    United States

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  • George Washington University Medical Center

    Washington, District of Columbia 20037
    United States

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  • MedStar Washington Hospital Center

    Washington, District of Columbia 20010
    United States

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  • University of Florida Health Science Center - Gainesville

    Gainesville, Florida 32610
    United States

    Active - Recruiting

  • Miami Cancer Institute

    Miami, Florida 33176
    United States

    Active - Recruiting

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho 83814
    United States

    Active - Recruiting

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho 83854
    United States

    Active - Recruiting

  • Kootenai Clinic Cancer Services - Sandpoint

    Sandpoint, Idaho 83864
    United States

    Active - Recruiting

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois 61704
    United States

    Active - Recruiting

  • Illinois CancerCare-Canton

    Canton, Illinois 61520
    United States

    Active - Recruiting

  • SIH Cancer Institute

    Carterville, Illinois 62918
    United States

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  • Illinois CancerCare-Carthage

    Carthage, Illinois 62321
    United States

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  • Northwestern University

    Chicago, Illinois 60611
    United States

    Active - Recruiting

  • University of Illinois

    Chicago, Illinois 60612
    United States

    Active - Recruiting

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois 60115
    United States

    Active - Recruiting

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois 62526
    United States

    Active - Recruiting

  • Decatur Memorial Hospital

    Decatur, Illinois 62526
    United States

    Active - Recruiting

  • Illinois CancerCare-Dixon

    Dixon, Illinois 61021
    United States

    Active - Recruiting

  • Crossroads Cancer Center

    Effingham, Illinois 62401
    United States

    Active - Recruiting

  • Illinois CancerCare-Eureka

    Eureka, Illinois 61530
    United States

    Active - Recruiting

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois 61401
    United States

    Active - Recruiting

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois 60134
    United States

    Active - Recruiting

  • Northwestern Medicine Glenview Outpatient Center

    Glenview, Illinois 60026
    United States

    Active - Recruiting

  • Northwestern Medicine Grayslake Outpatient Center

    Grayslake, Illinois 60030
    United States

    Active - Recruiting

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois 61443
    United States

    Active - Recruiting

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois 60045
    United States

    Active - Recruiting

  • Illinois CancerCare-Macomb

    Macomb, Illinois 61455
    United States

    Active - Recruiting

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois 62269
    United States

    Active - Recruiting

  • Northwestern Medicine Oak Brook

    Oak Brook, Illinois 60523
    United States

    Active - Recruiting

  • Northwestern Medicine Orland Park

    Orland Park, Illinois 60462
    United States

    Active - Recruiting

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois 61350
    United States

    Active - Recruiting

  • Illinois CancerCare-Pekin

    Pekin, Illinois 61554
    United States

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  • Illinois CancerCare-Peoria

    Peoria, Illinois 61615
    United States

    Active - Recruiting

  • Illinois CancerCare-Peru

    Peru, Illinois 61354
    United States

    Active - Recruiting

  • Illinois CancerCare-Princeton

    Princeton, Illinois 61356
    United States

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  • Memorial Hospital East

    Shiloh, Illinois 62269
    United States

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  • Southern Illinois University School of Medicine

    Springfield, Illinois 62702
    United States

    Active - Recruiting

  • Springfield Clinic

    Springfield, Illinois 62702
    United States

    Active - Recruiting

  • Springfield Memorial Hospital

    Springfield, Illinois 62781
    United States

    Active - Recruiting

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois 60555
    United States

    Active - Recruiting

  • Illinois CancerCare - Washington

    Washington, Illinois 61571
    United States

    Active - Recruiting

  • Mary Greeley Medical Center

    Ames, Iowa 50010
    United States

    Active - Recruiting

  • McFarland Clinic - Ames

    Ames, Iowa 50010
    United States

    Active - Recruiting

  • McFarland Clinic - Boone

    Boone, Iowa 50036
    United States

    Active - Recruiting

  • Mercy Hospital

    Cedar Rapids, Iowa 52403
    United States

    Active - Recruiting

  • Oncology Associates at Mercy Medical Center

    Cedar Rapids, Iowa 52403
    United States

    Active - Recruiting

  • McFarland Clinic - Trinity Cancer Center

    Fort Dodge, Iowa 50501
    United States

    Active - Recruiting

  • McFarland Clinic - Jefferson

    Jefferson, Iowa 50129
    United States

    Active - Recruiting

  • McFarland Clinic - Marshalltown

    Marshalltown, Iowa 50158
    United States

    Active - Recruiting

  • Lafayette Family Cancer Center-EMMC

    Brewer, Maine 04412
    United States

    Active - Recruiting

  • UPMC Western Maryland

    Cumberland, Maryland 21502
    United States

    Active - Recruiting

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02215
    United States

    Active - Recruiting

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts 01805
    United States

    Active - Recruiting

  • Lahey Medical Center-Peabody

    Peabody, Massachusetts 01960
    United States

    Active - Recruiting

  • Bronson Battle Creek

    Battle Creek, Michigan 49017
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan 48114
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan 48188
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan 48118
    United States

    Active - Recruiting

  • Cancer Hematology Centers - Flint

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Genesee Hematology Oncology PC

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan 49503
    United States

    Active - Recruiting

  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan 49503
    United States

    Active - Recruiting

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Active - Recruiting

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007
    United States

    Active - Recruiting

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan 48912
    United States

    Active - Recruiting

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan 48154
    United States

    Active - Recruiting

  • Trinity Health Muskegon Hospital

    Muskegon, Michigan 49444
    United States

    Active - Recruiting

  • Corewell Health Lakeland Hospitals - Niles Hospital

    Niles, Michigan 49120
    United States

    Active - Recruiting

  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    Norton Shores, Michigan 49444
    United States

    Active - Recruiting

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan 48341
    United States

    Active - Recruiting

  • Corewell Health Reed City Hospital

    Reed City, Michigan 49677
    United States

    Active - Recruiting

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    Saint Joseph, Michigan 49085
    United States

    Active - Recruiting

  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital

    Saint Joseph, Michigan 49085
    United States

    Active - Recruiting

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Active - Recruiting

  • University of Michigan Health - West

    Wyoming, Michigan 49519
    United States

    Active - Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan 48197
    United States

    Active - Recruiting

  • Essentia Health Saint Joseph's Medical Center

    Brainerd, Minnesota 56401
    United States

    Active - Recruiting

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota 56636
    United States

    Active - Recruiting

  • Essentia Health Cancer Center

    Duluth, Minnesota 55805
    United States

    Active - Recruiting

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota 55746
    United States

    Active - Recruiting

  • Essentia Health Sandstone

    Sandstone, Minnesota 55072
    United States

    Active - Recruiting

  • Essentia Health Virginia Clinic

    Virginia, Minnesota 55792
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    Columbus, Mississippi 39705
    United States

    Active - Recruiting

  • Baptist Cancer Center-Grenada

    Grenada, Mississippi 38901
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Union County

    New Albany, Mississippi 38652
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Oxford

    Oxford, Mississippi 38655
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Desoto

    Southhaven, Mississippi 38671
    United States

    Active - Recruiting

  • Saint Francis Medical Center

    Cape Girardeau, Missouri 63703
    United States

    Active - Recruiting

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri 63141
    United States

    Active - Recruiting

  • Parkland Health Center - Farmington

    Farmington, Missouri 63640
    United States

    Active - Recruiting

  • Mercy Hospital Saint Louis

    Saint Louis, Missouri 63141
    United States

    Active - Recruiting

  • Missouri Baptist Medical Center

    Saint Louis, Missouri 63131
    United States

    Active - Recruiting

  • Siteman Cancer Center at Christian Hospital

    Saint Louis, Missouri 63136
    United States

    Active - Recruiting

  • Siteman Cancer Center-South County

    Saint Louis, Missouri 63129
    United States

    Active - Recruiting

  • Washington University School of Medicine

    Saint Louis, Missouri 63110
    United States

    Active - Recruiting

  • Siteman Cancer Center at Saint Peters Hospital

    Saint Peters, Missouri 63376
    United States

    Active - Recruiting

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri 63670
    United States

    Active - Recruiting

  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri 63080
    United States

    Active - Recruiting

  • BJC Outpatient Center at Sunset Hills

    Sunset Hills, Missouri 63127
    United States

    Active - Recruiting

  • Community Hospital of Anaconda

    Anaconda, Montana 59711
    United States

    Active - Recruiting

  • Billings Clinic Cancer Center

    Billings, Montana 59101
    United States

    Active - Recruiting

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana 59715
    United States

    Active - Recruiting

  • Benefis Sletten Cancer Institute

    Great Falls, Montana 59405
    United States

    Active - Recruiting

  • Community Medical Center

    Missoula, Montana 59804
    United States

    Active - Recruiting

  • Jefferson Cherry Hill Hospital

    Cherry Hill, New Jersey 08002
    United States

    Active - Recruiting

  • Morristown Medical Center

    Morristown, New Jersey 07960
    United States

    Active - Recruiting

  • Sidney Kimmel Cancer Center Washington Township

    Sewell, New Jersey 08080
    United States

    Active - Recruiting

  • Overlook Hospital

    Summit, New Jersey 07902
    United States

    Active - Recruiting

  • Hematology Oncology Associates of CNY at Camillus

    Camillus, New York 13031
    United States

    Active - Recruiting

  • Hematology Oncology Associates of Central New York-East Syracuse

    East Syracuse, New York 13057
    United States

    Active - Recruiting

  • Mount Sinai Chelsea

    New York, New York 10011
    United States

    Active - Recruiting

  • Mount Sinai Hospital

    New York, New York 10029
    United States

    Active - Recruiting

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina 27599
    United States

    Active - Recruiting

  • Essentia Health Cancer Center-South University Clinic

    Fargo, North Dakota 58103
    United States

    Active - Recruiting

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio 44011
    United States

    Active - Recruiting

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio 44122
    United States

    Active - Recruiting

  • Case Western Reserve University

    Cleveland, Ohio 44106
    United States

    Active - Recruiting

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210
    United States

    Active - Recruiting

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio 44060
    United States

    Active - Recruiting

  • Cancer Centers of Southwest Oklahoma Research

    Lawton, Oklahoma 73505
    United States

    Active - Recruiting

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104
    United States

    Active - Recruiting

  • Oregon Health and Science University

    Portland, Oregon 97239
    United States

    Active - Recruiting

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania 18103
    United States

    Active - Recruiting

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania 18017
    United States

    Active - Recruiting

  • UPMC Hillman Cancer Center at Butler Health System

    Butler, Pennsylvania 16001
    United States

    Active - Recruiting

  • Geisinger Medical Center

    Danville, Pennsylvania 17822
    United States

    Active - Recruiting

  • Pocono Medical Center

    East Stroudsburg, Pennsylvania 18301
    United States

    Active - Recruiting

  • UPMC Hillman Cancer Center Erie

    Erie, Pennsylvania 16505
    United States

    Active - Recruiting

  • UPMC Cancer Centers - Arnold Palmer Pavilion

    Greensburg, Pennsylvania 15601
    United States

    Active - Recruiting

  • UPMC Pinnacle Cancer Center/Community Osteopathic Campus

    Harrisburg, Pennsylvania 17109
    United States

    Active - Recruiting

  • Geisinger Medical Center-Cancer Center Hazleton

    Hazleton, Pennsylvania 18201
    United States

    Active - Recruiting

  • Lehigh Valley Hospital-Hazleton

    Hazleton, Pennsylvania 18201
    United States

    Active - Recruiting

  • UPMC-Johnstown/John P. Murtha Regional Cancer Center

    Johnstown, Pennsylvania 15901
    United States

    Active - Recruiting

  • Geisinger Medical Oncology-Lewisburg

    Lewisburg, Pennsylvania 17837
    United States

    Active - Recruiting

  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

    Mechanicsburg, Pennsylvania 17050
    United States

    Active - Recruiting

  • UPMC Hillman Cancer Center - Monroeville

    Monroeville, Pennsylvania 15146
    United States

    Active - Recruiting

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania 19107
    United States

    Active - Recruiting

  • UPMC-Passavant Hospital

    Pittsburgh, Pennsylvania 15237
    United States

    Active - Recruiting

  • UPMC-Saint Clair Hospital Cancer Center

    Pittsburgh, Pennsylvania 15243
    United States

    Active - Recruiting

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania 15232
    United States

    Active - Recruiting

  • Community Medical Center

    Scranton, Pennsylvania 18510
    United States

    Active - Recruiting

  • Geisinger Wyoming Valley/Henry Cancer Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Active - Recruiting

  • Divine Providence Hospital

    Williamsport, Pennsylvania 17754
    United States

    Active - Recruiting

  • Smilow Cancer Hospital Care Center - Westerly

    Westerly, Rhode Island 02891
    United States

    Active - Recruiting

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina 29316
    United States

    Active - Recruiting

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina 29640
    United States

    Active - Recruiting

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina 29605
    United States

    Active - Recruiting

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina 29615
    United States

    Active - Recruiting

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina 29605
    United States

    Active - Recruiting

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina 29650
    United States

    Active - Recruiting

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina 29672
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee 38017
    United States

    Active - Recruiting

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee 38120
    United States

    Active - Recruiting

  • The Don and Sybil Harrington Cancer Center

    Amarillo, Texas 79106
    United States

    Active - Recruiting

  • Houston Methodist San Jacinto Hospital

    Baytown, Texas 77521
    United States

    Active - Recruiting

  • Houston Methodist Cypress Hospital

    Cypress, Texas 77429
    United States

    Active - Recruiting

  • Houston Methodist Hospital

    Houston, Texas 77030
    United States

    Active - Recruiting

  • Houston Methodist West Hospital

    Houston, Texas 77094
    United States

    Active - Recruiting

  • Methodist Willowbrook Hospital

    Houston, Texas 77070
    United States

    Active - Recruiting

  • Houston Methodist Saint John Hospital

    Nassau Bay, Texas 77058
    United States

    Active - Recruiting

  • Houston Methodist Sugar Land Hospital

    Sugar Land, Texas 77479
    United States

    Active - Recruiting

  • Houston Methodist The Woodlands Hospital

    The Woodlands, Texas 77385
    United States

    Active - Recruiting

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia 23235
    United States

    Active - Recruiting

  • Virginia Commonwealth University/Massey Cancer Center

    Richmond, Virginia 23298
    United States

    Active - Recruiting

  • West Virginia University Charleston Division

    Charleston, West Virginia 25304
    United States

    Active - Recruiting

  • West Virginia University Healthcare

    Morgantown, West Virginia 26506
    United States

    Active - Recruiting

  • Duluth Clinic Ashland

    Ashland, Wisconsin 54806
    United States

    Active - Recruiting

  • Froedtert Menomonee Falls Hospital

    Menomonee Falls, Wisconsin 53051
    United States

    Active - Recruiting

  • Medical College of Wisconsin

    Milwaukee, Wisconsin 53226
    United States

    Active - Recruiting

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin 53149
    United States

    Active - Recruiting

  • Drexel Town Square Health Center

    Oak Creek, Wisconsin 53154
    United States

    Active - Recruiting

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin 53066
    United States

    Active - Recruiting

  • ProHealth Waukesha Memorial Hospital

    Waukesha, Wisconsin 53188
    United States

    Active - Recruiting

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin 53188
    United States

    Active - Recruiting

  • Froedtert West Bend Hospital/Kraemer Cancer Center

    West Bend, Wisconsin 53095
    United States

    Active - Recruiting

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