Registry for Automated Mechanical VEntilation in Adults

Last updated: January 15, 2026
Sponsor: Hamilton Medical AG
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Injury

Respiratory Failure

Treatment

Non-invasive ventilation, Invasive mechanical ventilation, high-flow nasal oxygen

Clinical Study ID

NCT06655805
HM - RAVE
  • Ages > 18
  • All Genders

Study Summary

The aim of the here proposed study is to assess safety, performance and provide real world evidence (RWE) of the Hamilton Medical AG automated mechanical ventilation software packages in consecutive critically ill patients admitted to the intensive care unit.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Age ≥ 18 years. Any patient in need of HFNO, NIV and IMV at some time during its ICU stay.

Exclusion

Exclusion Criteria:

Expected to be weaned from HFNO, NIV within 2 hours. Expected to be weaned and extubated from IMV without subsequent need of HFNO or NIV support within 2 hours.

Expected to be transferred to another non-participating ICU within 2 hours. Moribund subject: death expected within 2 hours.

Study Design

Total Participants: 1000
Treatment Group(s): 1
Primary Treatment: Non-invasive ventilation, Invasive mechanical ventilation, high-flow nasal oxygen
Phase:
Study Start date:
September 23, 2024
Estimated Completion Date:
December 31, 2030

Study Description

The harmful effect of invasive mechanical ventilation can be prevented by intensive training of ICU physicians, respiratory therapists, and ICU nurses on the one hand, and by improvement of the technology installed in ventilators on the other hand. Advanced mechanical ventilation modes use new technologies to assist physiology, optimize gas exchange and minimize ventilator induced lung injury. Modes such as proportional assist ventilation and neuronally adjusted ventilatory assist deliver assisted ventilation proportional to the patient's effort, improving ventilator patient synchrony. The Adaptive Support Ventilation (ASV) mode automatically adjust tidal volume and respiratory rate based on patient's respiratory mechanics to protect from mechanical ventilator induced lung injury, hence deliver safe mechanical ventilation. The implementation of advanced closed-loop systems automates medical reasoning and has potential to improve patient ventilator interactions, the time spent on mechanical ventilation, staff workload and potentially outcome.

Connect with a study center

  • HOCH Health Ostschweiz, Clinics for Intensive Care Medicine, Surgical ICU

    Sankt Gallen 2658822, Canton of St. Gallen 2658821 9007
    Switzerland

    Active - Recruiting

  • Kantonsspital Chur

    Chur, Graubünden 7000
    Switzerland

    Site Not Available

  • Kantonsspital Chur

    Chur 2661169, Kanton Graubünden 2660522 7000
    Switzerland

    Active - Recruiting

  • HOCH Health Ostschweiz, Clinics for Intensive Care Medicine, Medical ICU

    Sankt Gallen 2658822, St.Gallen 9007
    Switzerland

    Active - Recruiting

  • HOCH Health Ostschweiz, Clinics for Intensive Care Medicine, Medical ICU

    St Gallen, St.Gallen 9007
    Switzerland

    Active - Recruiting

  • HOCH Health Ostschweiz, Clinics for Intensive Care Medicine, Surgical ICU

    St Gallen, 9007
    Switzerland

    Site Not Available

  • Kantonsspital Winterthur, Zentrum für Intensivmedizin

    Winterthur 2657970, 8400
    Switzerland

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.