Correlation Between PLA Levels and Disease Severity in Patients With Sepsis Cardiac Insufficiency

Inclusion Criteria:

• Sepsis cardiac insufficiency group

1. From April 2024 to December 2026, in the first ICU area of Dongzhimen Hospital,Beijing University of Chinese Medicine, Hospitalized patients in Zone II;

2. consistent with the diagnosis of sepsis cardiac insufficiency;

3. Age ≥ 50 and ≤ 90 years old;

4. SOFA score≥ 2 points;

5. Within 24 hours of the diagnosis of cardiac insufficiency in sepsis;

6. The patient or his/her family members sign the informed consent form. Healthysubjects

7. Aged ≥ 50 and ≤ 90 years old, permanent residents of Beijing community;

8. Good health (blood routine, liver and kidney function, blood lipids, bloodcoagulation, no obvious abnormalities, no diagnosis cardiac insufficiency,acute coronary syndrome, old myocardial infarction, or cardiomyopathy);

9. There is no history of long-term use of drugs that affect platelet function andcoagulation function, and those who are willing to cooperate with the testCrowd;

10. The subject himself signed the informed consent form.

Exclusion Criteria:

1. Diagnosed with acute coronary syndrome, old myocardial infarction, and coronaryheart disease revascularization of patients; (2) Cardiac insufficiency due tocardiomyopathy, such as hypertrophic cardiomyopathy, dilated cardiomyopathy,myocardial amyloidosis, diabetic cardiomyopathy, hypothyroidic cardiomyopathy,etc.; (3) Due to heart knots Cardiac insufficiency caused by structuralabnormalities, arrhythmias, cor pulmonale, nephroheart syndrome, etc.; (4)Impact Survival of severe primary diseases, including: uncontrolled malignanttumors that have metastasized in multiple places and cannot be resected, andblood disease, novel coronavirus infection and HIV, etc.; (5) Liver and kidneydysfunction with a single SOFA score of ≥3 points in liver or kidneyhandicappers; (6) Those who have been continuously using immunosuppressants ororgan transplantation in the past 6 months; (7) 7 consecutive days prior toenrollment Those who have used corticosteroids, converted to methylprednisolonedose≥ 20mg/day; (8) Pregnant and lactating women; (9) Take or Injection ofdrugs that affect platelet function and coagulation function; (10) Those whohave participated in other clinical trials within 30 days.