Mood Disorders in Multiple Sclerosis Patients

Phase

N/A

Condition

Multiple Sclerosis

Bipolar Disorder

Depression (Major/severe)

Treatment

N/A

Clinical Study ID

NCT06652308

MSMood2024-SDU

Ages 18-65
All Genders

Study Summary

This study investigates the frequency of unipolar and bipolar mood disorders in patients with multiple sclerosis. MS is a chronic condition that affects the central nervous system, and previous research suggests that mood disorders, such as depression and bipolar disorder, may occur more frequently in MS patients compared to the general population.

A retrospective analysis of 85 patients diagnosed with MS was conducted, evaluating lifetime experiences with mood disorders using structured clinical interviews. The goal is to better understand the prevalence of these mood disorders and to raise awareness of the importance of mental health care in patients with MS. The findings highlight that mood disorders, particularly bipolar disorder, are more common in MS patients than previously thought. This information can help healthcare providers improve screening, diagnosis, and treatment for MS patients suffering from mood disorders.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Diagnosis of Multiple Sclerosis: Participants must have a confirmed diagnosis ofmultiple sclerosis (MS) by a qualified neurologist.
Age Range: Participants must be between 18 and 65 years of age.
Informed Consent: Participants must provide informed consent to participate in thestudy.
Geographic Location: Participants must reside in Tehran, Iran.

Exclusion

Exclusion Criteria:

Other Neurological Disorders: Individuals with a diagnosis of any other neurologicaldisease (e.g., epilepsy, Parkinson's disease) will be excluded.
Head Trauma: History of head trauma that resulted in impaired consciousness ormemory loss.
Seizures: A history of seizures that could affect mood.
Substance Dependence: A history of substance dependence as per DSM-IV criteria.
Other Physical Illnesses: Any systemic or physical diseases that could lead to moodsymptoms.

Study Design

July 01, 2024

September 30, 2024

Study Description

This study is a retrospective cohort analysis designed to examine the lifetime prevalence of unipolar and bipolar mood disorders in patients with multiple sclerosis. MS is a chronic, demyelinating condition of the central nervous system that leads to varying degrees of neurological impairment. Previous studies have shown that mood disorders, particularly depression and bipolar disorder, are more prevalent in patients with MS than in the general population.

Data from 85 patients (45 females and 40 males) diagnosed with MS were analyzed, focusing on psychiatric history through structured clinical interviews. The study evaluated the presence of mood disorders, including major depressive disorder, bipolar disorder types I and II, dysthymia, and unclassified mood disorders. Data were collected using DSM-IV criteria to ensure consistency in diagnosis.

The results demonstrate that mood disorders, especially bipolar disorder, are more frequent than previously reported in this patient population. These findings underscore the need for improved mental health screening and treatment for MS patients, as managing psychiatric comorbidities can significantly enhance overall quality of life. The study emphasizes the importance of integrating psychiatric care into routine MS management.

Connect with a study center

Shandong University
Jinan,
China
Site Not Available

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