The Impact of Soft Contact Lenses on the Corneal Neuromediators and Optical Quality in High Myopia Prior to SMILE

Last updated: October 18, 2024
Sponsor: yuhao shao
Overall Status: Active - Recruiting

Phase

N/A

Condition

Myopia

Treatment

This study does not involve any interventions

Clinical Study ID

NCT06650306
SHSY-IEC-5.0/23K74/P01
  • Ages 18-45
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

To investigate the influence of Neuromediators expression in corneal stromal lenticules and corneal injury repair after small incision extraction

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age ≥ 18 years with stable refraction for at least two years;

  • spherical equivalent (SE) < -6.00 D;

  • corrected distance visual acuity of 20/20 or better;

  • no history of using rigid gas permeable lenses or orthokeratology (OK) lenses priorto examination

Exclusion

Exclusion Criteria:

  • a history of moderate to severe dry eye as well as any ocular or systemic diseasethat would contraindicate laser refractive surgery.

Study Design

Total Participants: 80
Treatment Group(s): 1
Primary Treatment: This study does not involve any interventions
Phase:
Study Start date:
October 18, 2024
Estimated Completion Date:
June 30, 2026

Study Description

This study included 160 eyes from high myopia patients who underwent Small Incision Lenticule Extraction. Patients were devided into three groups based on duration of wearing SCLs: > 10 years group, ≤ 10 years group, and NW group (not SCLs). Corneal higher-order aberrations and densitometry were evaluated using a Pentacam system. Neuromediator levels in corneal stromal lenticules were analyzed using ELISA and immunofluorescence

Connect with a study center

  • Shanghai Tenth People's Hospital

    Shanghai, Shanghai
    China

    Active - Recruiting

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