A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)

Inclusion Criteria:

• are 18 years of age or older

• male or female, if of childbearing potential, strict contraception required

• have ALS confirmed by the trial doctors using different tests.

• have mild symptoms of ALS as measured by the ALSFRS-R questionnaire (total score >=30).

• have had symptoms of ALS (weakness) within 24 months of taking part in this trial.

• have not received treatment for ALS or are currently on a stable dose of an approvedtreatment for ALS.

• have the ability to slowly exhale a volume of air at least 60% of what is expectedfor the participant's sex, height and age.

Exclusion Criteria:

• Use of other investigational drugs within 5 half-lives of screening, or within 30days (e.g., small molecules) / or until the expected pharmacodynamic effect hasreturned to baseline (e.g., biologics), whichever is longer; or longer if requiredby local regulations.

• Women of child-bearing potential, defined as all women physiologically capable ofbecoming pregnant, unless they are using highly effective methods of contraceptionwhile taking study treatment and for 24 weeks after stopping study medication.

• History or current diagnosis of cardiac conditions or ECG abnormalities indicatingsignificant risk of safety for participants in the study.

• Clinical evidence of liver or renal disease/injury.

• Laboratory evidence of hematological abnormalities

• Presence of unstable psychiatric disease, cognitive impairment, neurological diseaseother than ALS, dementia or substance abuse that would impair ability of theparticipant to provide informed consent, in the investigator's opinion.

• Participants that reported 'yes' on any suicidal ideation section except for the "Non-Suicidal Self-Injurious Behavior" in the past 2 years as per C-SSRS.

• Presence of cancer, HIV, Hep B, Hep C, tuberculosis, uncontrolled diabetes

• History of active severe respiratory disease, including Chronic ObstructivePulmonary Disease, interstitial lung disease or pulmonary fibrosis.

• Taking any prohibited medications