A Trial of SHR-A2102 With Antitumor Therapy in Advanced Urothelial Carcinoma

Inclusion Criteria:

1. Competent to comprehend, sign, and date an informed consent form.

2. Male or female subjects must be age 18 or older.

3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

4. Subjects must have histologically documented, unresectable locally advanced or

5. Histologically confirmed locally advanced or metastatic urothelial cancer.Phase Ib,subjects must have failed, be intolerant or refused the standard treatment; PhaseII, subjects must not have received systemic antitumor therapy for locally advancedunresectable or metastatic urothelial carcinoma.

6. An archival tumor tissue sample or a fresh tissue sample should be provided.

7. Subjects must have measurable disease according to RECIST (version 1.1).

Exclusion Criteria:

1. Subjects with not adequately treated, or uncontrollable , or active CNS metastases.

2. Subjects who have previously received TOPO1-based ADCs.

3. Subjects who have received anti-cancer treatment within 4 weeks prior the first doseof study treatment.

4. Subjects who have received radiotherapy within 14 days , or chest radiotherapy > 30Gy within 6 months prior to the first dose of study drug.

5. Subjects with ongoing clinically significant toxicity associated with priortreatment that has not resolved to ≤ Grade 1.

6. Subjects who have received systemic immunosuppressant treatment within 14 days priorthe first dose of study treatment.

7. Subjects who have known or suspected interstitial pneumonitis.

8. Phase Ib: Subjects who have had≥ Grade 3 irAEs during the previous treatment withICIs.

9. Subjects who have any active, known or suspected autoimmune diseases.

10. Subjects who have moderate or severe ascites with clinical symptoms, or uncontrolledor moderate or above pleural effusion, or pericardial effusion.

11. Subjects who have uncontrolled cardiac diseases or cardiac clinical symptoms.