Study of the Impact of Cataract Surgery on the Corneal Epithelium and Ocular Surface of Diabetic Patients

Last updated: October 9, 2024
Sponsor: University Hospital, Strasbourg, France
Overall Status: Active - Recruiting

Phase

N/A

Condition

Eye Disorders/infections

Vision Loss

Eye Disease

Treatment

N/A

Clinical Study ID

NCT06638424
9246
  • Ages > 18
  • All Genders

Study Summary

Diabetes is one of the most common fatal metabolic diseases in the world. Diabetes-induced ocular surface alterations are poorly understood. Indeed, it was once thought that the cornea, avascular, was immune to the effects of diabetes. A growing number of publications now demonstrate the opposite. These alterations affect up to 70% of diabetic patients at some point in the progression of their diabetes.

Another common complication of diabetes is the early development of a cataract, requiring surgery. Diabetic patients are therefore more likely to require surgery at an early age than the general population.

Diabetes and cataract surgery both induce corneal changes. Cataract surgery in diabetic patients is therefore at greater risk of corneal complications. Diabetes induces dysfunction of the main lacrimal gland, corneal neuropathy, meibomian dysfunction and a decrease in conjunctival mucus cells. Diabetic patients are therefore particularly at risk of exacerbation or appearance of alterations of the corneal epithelium and the ocular surface in postoperative cataract surgery.

Therefore, it seems necessary to evaluate the impact of cataract surgery on the ocular surface and corneal epithelium of diabetic patients, in order to improve their management.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patient (≥18 years);

  • Patient operated on for cataract at HUS between January 2022 and January 2024;

  • Patient who did not express his opposition to the reuse of his data for scientificresearch purposes;

  • Patient who benefited from the measurement of the above-mentioned judgment criteriaduring his pre- and post-operative consultations.

Exclusion

Exclusion Criteria:

  • Presence in the medical file of the subject's opposition to the reuse of his datafor scientific research purposes.

  • Prolonged use of stored eye drops;

  • Documented etiology of chronic alteration of the ocular surface (shingles, herpes,Gougerot-Sjogren syndrome, graft-versus-host disease);

  • Minor patient or under guardianship or curatorship.

Study Design

Total Participants: 150
Study Start date:
April 22, 2024
Estimated Completion Date:
April 22, 2025

Connect with a study center

  • Service d'Ophtalmologie - CHU de Strasbourg - France

    Strasbourg, 67091
    France

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.