HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)

Inclusion Criteria:

1. Age ≥16 years

2. Clinical history consistent with HAE-C1INH-Type 1 or -Type 2

3. Ability to provide evidence of HAE attacks (confirmed by the Investigator) to meetthe screening requirement

4. Must agree to refrain from the use of long-term prophylactic therapies from thestart of the screening period through the end of the Primary Observation Period. PImust be in agreement that it is medically acceptable for the participant to do so.

5. Must have access to, and the ability to use, on-demand medication(s) to treatpotential angioedema attacks

6. Adequate chemistry and hematology measures at screening

7. Must agree not to participate in another interventional study for the duration ofthis trial.

8. Must be capable of providing signed informed consent. Participants 16 to < 18 yearsof age, whose legal guardian provides informed consent, must provide assent.

9. Must agree to follow contraception requirements

Exclusion Criteria:

1. Concurrent diagnosis of any other type of recurrent angioedema or HAE with normalC1-INH

2. Have known negative reaction or hypersensitivity to any lipid nanoparticles (LNP)component.

3. Any condition that, in the Investigator's opinion, could adversely affect the safetyof the subject.

4. Unwilling to comply with study procedures.