In Vitro Maturation of Human Eggs

Last updated: October 7, 2024
Sponsor: Colorado Center for Reproductive Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Infertility

Reproductive Health

In Vitro Fertilization

Treatment

IVM

Clinical Study ID

NCT06633120
20141020
  • Ages < 38
  • Female

Study Summary

CCRM Fertility, a global pioneer in fertility treatment, research and science, is seeking participants for a new study on in vitro maturation (IVM). IVM requires less hormones to stimulate the ovaries than IVF, making it more affordable than IVF with fewer side effects. Participants that qualify for the study will receive a free cycle of IVM treatment at CCRM Fertility and including a new patient consultation, fertility testing, preimplantation genetic testing for aneuploidies (PGT-A), anesthesia and some medication

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Infertile women diagnosed with PCOS or polycystic ovaries, or infertile women withgood ovarian reserve

  • Antral follicle count (AFC) greater than 24

  • AMH greater than 3.5 ng/ml

  • Body Mass Index less than 35

  • Accept to have embryos biopsied for PGT

  • Intend to perform embryo transfer within 4 months after completing the IVM cycle

  • Paternal (or donor) age &lt;45, ejaculated sperm collection only (partner frozen anddonor sperm acceptable), sperm morphology (strict criteria) &gt;1%, motility &gt; 20% and sperm count &gt; 10 million per ml (so samples can be prepared throughstandard procedure)

Exclusion

Exclusion Criteria:

  • More than 2 failed IVF cycles

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: IVM
Phase:
Study Start date:
February 03, 2023
Estimated Completion Date:
August 30, 2030

Study Description

Patients will undergo a complete IVF workup to qualify for study. Once passing their baseline appointment patients will undergo a three day low dose stimulation followed by egg retrieval 18-22 hours post last medication dosage. Immature oocytes will be retrieved from the ovaries via ultrasound guided TV aspiration and matured overnight in the laboratory. Mature oocytes will be fertilized via ICSI the following day and cultured to the blastocyst stage. Biopsy of the first 14 blastocysts are included with this package, patients have the option biopsy additional embryos if available. Biopsies will be sent for PGTA testing. This study also includes preparation for and the first frozen embryo transfer. Some FET medication is included as well as testing through the first pregnancy test.

Connect with a study center

  • Colorado Center for Reproductive Medicine

    Lone Tree, Colorado 80124
    United States

    Active - Recruiting

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